Post Doc Research Scientist – Neurodegeneration

Organization Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism.

We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. #We Are Lilly

We are seeking a highly motivated postdoctoral scientist with strong in vivo two photon imaging skills to perform groundbreaking translational research in Alzheimer's disease. Your work will focus on investigating mechanisms of amyloid immunotherapy-related microhemorrhage in Alzheimer's disease using in vivo two-photon imaging of amyloid mouse models.

• Investigate the molecular and cellular processes underlying amyloid immunotherapy-induced microhemorrhage using advanced in vivo two-photon imaging techniques in real time
• Evaluate the neuroinflammatory roles of central and peripheral immune cells in amyloid immunotherapy induced microhemorrhage pathogenesis
• Explore novel mechanisms that may contribute to toxicity risks associated with amyloid immunotherapy
• Collaborate with scientists across neuroscience and other functional areas in a highly collaborative, multidisciplinary team environment
• Present findings at national and international conferences and publish in high-quality, peer-reviewed journals

• PhD in Neuroscience or other related field
• Experience in in vivo dosing (IV,IP, SC), mouse brain stereotactic surgery, in vivo two photon imaging, image analysis
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1

• Background in neurodegeneration and/or neurovascular biology research
• Prior working experience with Alzheimer’s disease or other neurodegenerative mouse models
• Experience in developing image analysis workflows (Python, MATLAB, R, Imaris)
• Experience in histologic post hoc brain tissue analysis (IF, IHC, RNAScope)
• Experience in antibody conjugation for fluorescence dye labeling
• Proficient in data analysis and presentation
• Excellent communication skills (oral and written) along with a strong publication record.

This position is not permanent. It is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years.