VP, Program & Portfolio Management

Job Description

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology.

Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington’s disease, as well as a clinical program in obesity and a preclinical program in NASH/MASH. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

The Vice President (VP) of Program & Portfolio Management is a critical leadership role responsible for driving the successful execution of the company’s clinical development programs from early-stage research through pivotal clinical trials and, ultimately, toward regulatory approval and commercialization. This successful candidate will support enterprise level strategic decision making by providing a critical interface and information flow between Program and Project leads and the Executive Team.

Reporting directly to the Chief Financial Officer, the VP of Program Management will create, lead, and optimize cross-functional teams, ensuring that all programs are aligned with corporate objectives, timelines, budgets, and regulatory requirements.

• Advanced degree (PhD, MD, or equivalent preferred) in life sciences, biomedical engineering, or related field; MBA or other business qualification a plus.
• Minimum of 15 years progressive experience in biotech, pharmaceutical, or life sciences, with at least 7 years in program/project management leadership roles.
• Demonstrated experience managing complex, multi-disciplinary programs through all phases of drug discovery, development, and/or commercialization.
• Demonstrated enterprise and team leadership and cross-functional collaboration skills including the ability to influence without authority when needed.
• Exceptional organizational, planning, and execution skills, with a track record of delivering on high-stakes deadlines with exceptional attention to detail.
• Skilled in project management methods, tools, and reporting.
• Outstanding problem-solving, conflict resolution, and negotiation abilities.
• Excellent written and verbal communication skills, including executive-level presentation and reporting.
• Strong familiarity with regulatory, clinical, and commercial dynamics in the biotech industry.

• Oversee, in partnership with the Executive Team, the continuing development and assessment of Wave’s R&D portfolio and platform initiatives.
• Ensure individual program strategies, including their financial, operational, and business considerations, are aligned with Wave’s corporate strategy and that key program and platform information and implications are effectively and appropriately communicated to the Executive Team and the Board.
• Lead and oversee, in partnership with key stakeholders, the identification and assessment of:
  • Potentially new targets with an eye towards ways in which Wave’s platform can provide a unique advantage.
  • Key research, discovery and/or CMC initiatives and projects that strengthen and inform Wave’s platform.
• Interface with Corporate Development to identify opportunities within the portfolio and/or platform to support current and future partnerships.
• Partner with Corporate Communications and Investor Relations to enable impactful communication of relevant milestones and data.
• Develop and facilitate processes and provide leadership and coaching to ensure global program leaders and managers provide effective leadership to program, platform, and CMC teams.
• Lead a team of program and project managers who build and drive high performing program/platform teams through…