Senior Director, Trade & Channel Operations

Senior Director, Trade & Channel Operations

Cambridge, MA

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical‑stage company currently focused on post‑bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

The Senior Director, Trade & Channel Operations will be responsible for building Amylyx’s U.S. distribution and channel model from the ground up in preparation for a future commercial launch of our lead product candidate. This individual will architect the distribution strategy, create the operational infrastructure necessary for launch, and partner cross‑functionally to ensure Amylyx is fully prepared to commercialize with excellence.

As a key member of the Market Access team, this role will influence launch readiness, customer service delivery, and ongoing performance across distribution partners.

Responsibilities

• Design and build Amylyx’s U.S. distribution model across specialty pharmacy, specialty distributor, and 3PL channels to support product launch
• Lead contracting strategy for specialty pharmacies and distributors, including negotiating distribution and service agreements, fee schedules, data requirements, and service levels
• Integrate distribution channels with service programs and field initiatives to enable a seamless customer experience
• Collaborate with Supply Chain and Finance to support 3PL operations, including order‑to‑cash processes, inventory management, data exchange, shipping, returns, and chargeback management
• Establish and manage noncommercial and free‑goods pharmacy operations
• Forecast and model channel performance, assess specialty pharmacy throughput, and provide recommendations to ensure timely, reliable patient access
• Develop distribution analytics including inventory visibility, service metrics, dispense data, time to therapy, and partner scorecards; lead specialty pharmacy QBRs
• Partner cross‑functionally with Supply Chain, Quality, Compliance, Legal, Finance, Patient Services, and Commercial Operations to ensure operational alignment and launch readiness
• Serve as a senior leader within Market Access, contributing to launch planning, forecasting, patient access workflows, and overall distribution strategy
• Continuously optimize post‑launch distribution operations by driving root‑cause remediation, vendor KPI management, and process improvements informed by field and service feedback.

Required Qualifications

• 12+ years of experience in biopharmaceutical trade and distribution, including leadership of specialty pharmacy and distributor channel networks
• Prior product launch experience in the US market
• Experience designing and implementing channel strategies for product launches
• Proven ability to assess, manage, and influence channel partner performance to contractual expectations
• Hands‑on experience with 3PL operations, serialization, state licensing, and compliant distribution processes
• Demonstrated strength in contract negotiation, vendor management, and commercial channel operations
• Deep understanding of payer reimbursement, hub/patient support integration, channel economics, and order‑to‑cash workflows
• Proven leadership experience, including managing large pharmaceutical vendors, with demonstrated people management skills
• Excellent communication, vendor management, analytical, and project execution capabilities

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax…