Senior Scientist- SBX Molecular Engineering

The Position

We work to advance science so that we all have more time with the people we love. You will engineer and synthesize the molecular building blocks for our novel technology. These building blocks translate DNA sequences into a simple to measure surrogate, the Xpandomer, which significantly improves the accuracy and throughput of nanopore sequencing. The Molecular Engineering group is passionate about the novel molecules they have developed and the impact SBX technology can have on advancing sequencing and patient outcomes.

We are looking for people who are excited about the significance of our technology and want to make SBX successful.

• Research, design and execute innovative and well‑controlled experiments, with high attention to detail.
• Lead, mentor and drive cross‑functional teams.
• Identify and troubleshoot problems in creative ways.
• Contribute to the definition and timely achievement of project goals.
• Develop SOPs to aid in the production of reagents and starting materials.
• Participate in the production of reagents and starting materials.
• Perform data analysis and protocol development.
• Maintain accurate, detailed and reliable laboratory records.
• Present findings at group or departmental meetings.
• Maintain the lab’s cleanliness and organization.
• Develop and propose improved processes to fulfill the above functions.

• 6 years of laboratory experience in advanced nucleotide/heterocyclic chemistry, phosphorus chemistry and/or complex/multi‑step organic synthesis, with a Bachelor’s degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field and 8 years of experience.
• Master’s degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field and 7 years of experience.
• PhD in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field and 4 years of experience.

• Demonstrated ability to understand and develop chemistry for nucleotides, phosphoramidites, heterocycles, amino acids and bio‑conjugations.
• Mature understanding of how to work with chemical and biochemical samples, including sample handling, reactivity, purification and storage.
• Technical background in next‑generation DNA sequencing.
• Experience with HPLC, MS, NMR, automated DNA synthesizers, inert atmosphere chambers, and manual pipetting.

Please include a cover letter outlining why you want to work with us, your specific interest in SBX technology and how you would contribute. This is important.

Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of Seattle, WA is $104,400 to $193,800. Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This position also qualifies for the benefits detailed here.

Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company’s policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of protected veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.