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Sr. Scientist - Cell

Job in Waltham - Middlesex County - MA Massachusetts - USA
Company: Repligen
Internship position
Listed on 2021-03-26
Job specializations:
  • Science
    Biochemistry, Chemistry, Biotech
  • Research/Development
    Postdoctoral Research Fellow
Job Description & How to Apply Below
Position:  Sr. Scientist - Cell Culture


Repligen Corporation (NASDAQ: RGEN) is a life sciences company focused on the development, production, and commercialization of high-value consumable and system products used in the process of manufacturing biological drugs. Our bioprocessing products are sold to major life sciences and biopharmaceutical companies worldwide.

Repligen has a range of single-use cell retention systems that are continuously being refined and updated to meet market needs. We are seeking a highly motivated, resourceful, detail-oriented professional to join our cell culture R&D team. The group is responsible for application research support for existing and new product development and evaluation.


Primary Job Responsibilities:

This position will play a key role in implementing cell culture principles and skilled practices in contributing to the overall R&D growth. The candidate will be a scientific leader in the upstream team, with responsibilities in executing bench-scale fed-batch and perfusion processes and characterization.

  • Lead upstream cell culture projects encompassing, study design, implementation, and data analysis to improve the process robustness and to evaluate novel applications and technologies.
  • Execute application-oriented high cell-density cultures for new and existing Repligen products. Laboratory activities will include seed expansion, fed-batch, perfusion, and clarification processes using mammalian cell lines.
  • Analyzing and troubleshooting cell culture processes by monitoring cell growth, viability, protein productivity, and other cell culture metabolites and process parameters. Serve as a technical leader in the implementation of bioreactor process scale-up parameters.
  • Proficient in developing protocols and reports for processes in shake flasks and stirred tank and single-use bioreactors using ATF/TFF and other perfusion systems.
  • Prepare presentation decks and data sets to effectively present experimental planning and results to the R&D and Product Management teams regularly.
  • Knowledgeable in protein quality and purification projects using chromatographic separation methods would be beneficial.
  • Designing experimental investigations, hollow fiber scale-up process, analyzing experimental data, discoveries, literature review, technical reports, and giving presentations internally and at scientific conferences.
  • Designing and executing novel application studies for market intelligence or to complement Repligen’s product lines based on feedback from the inter and intradepartmental
  • Mentor Upstream team members and deliver scientific guidance, and work collaboratively with technical leads and SMEs in manufacturing, engineering, and other associated departments.
  • Qualifications

    Minimum Requirements:

  • Degree in chemical engineering, biochemistry, or applicable fields
  • BS with 10+years or MS with 8+ years or Ph.D. with 6+ of industrial experience in a process or application development setting.
  • Extensive understanding in biological process sciences, upstream process development including aseptic techniques, and cell culture processes.
  • Experienced hands-on work in setting up a lab and bench-scale bioreactors, culturing cells, and optimizing feeding and perfusion strategies.
  • Demonstrated experience in the design of experiments (DoE), strong analytical and problem-solving skills to understand, and to contribute with novel solutions.
  • The ability to work independently and in a team setting
  • Excellent oral and written communication abilities and strong interpersonal skills to communicate with internal and external team members.
  • Additional Qualifications:

  • Additional experience with gene therapy applications and viral vaccines would be a plus.
  • Experience with continuous bioprocessing desirable but not necessary
  • Previous experience with hollow fiber membranes, determining critical flux, shear and TMP measurements
  • Position Requirements
    Less than 1 Year work experience
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