Junior technician – single cell genomics

Junior technician – single cell genomics

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

The Single Cell and Synthetic Genomics of Blood Formation lab (PI: Lars Velten) at CRG Barcelona is looking for a junior technician with initial experience in wet‑lab molecular biology or genomics work, and a strong motivation to develop into a genomics bench science expert.

Blood formation is an essential, biomedically highly relevant, and complex process of cellular differentiation. Our group works on basic science projects on gene regulation in blood stem cells (e.g. Frömel et al., Cell 2025 ), and more translational projects in the context of acute myeloid leukemia (AML) and pre‑leukemia (e.g. Beneyto‑Calabuig et al., Cell Stem Cell 2023 ). Recently, we have developed EPI‑Clone, a unique method to identify and characterize expanded stem cell clones independently of driver mutations and during physiological ageing (Scherer et al.,

Nature 2025 ). EPI‑Clone enables a new look at blood clonality and has wide applications in studies of ageing, pre‑leukemia, leukemia, and beyond. Our work on EPI‑Clone was widely covered by the popular press (Le Monde, Financial Times, El País and others).

The successful candidate will work on translational applications of EPI‑Clone. Specifically, they will support a senior technician in data generation. The position requires a strong study background in molecular biology, basic understanding of genomics and sequencing techniques, and a proven ability to work in the lab. It will allow you to develop a strong single‑cell genomics skill set in a fast‑paced research environment.

My interdisciplinary group investigates the biology of hematopoietic stem cells using a combination of single cell genomics, genetic screens, and computational biology. We strive to develop novel genomic and bioinformatic tools to answer longstanding questions in the field. In particular, we cover two main research lines, a) Gene regulation in healthy hematopoiesis) and b) Clonal function in ageing and disease. The lab has been established in January 2020 and currently consists of seven members:
Three PhD students, two postdocs and two senior technicians. We have received funding from the European Commission, the Spanish and German government, the Spanish Association Against Cancer and the European Hematology Association.

• You hold a Master of Science in a relevant field (molecular biology, human biology, biotechnology etc.)
• Alternatively, you hold a Bachelor of Science + 2 years of relevant work experience
• Experience in wet‑lab work in a molecular biology / genomics environment (at least 4 months hands‑on, e.g. an experimental master’s thesis)
• Familiarity with relevant methods (see below)

• Basic knowledge of bioinformatics (e.g. R programming or bash scripting)

• Master of Science in a relevant field (molecular biology, human biology, biotechnology etc.)
• Alternatively, Bachelor of Science + 2 years of relevant work experience

• You are proficient in English
• Spanish or German of advantage, but not required

• PCR and qPCR
• Molecular cloning
• Optional:
  Flow cytometry / FACS
• Optional:
  Genomics and single cell genomics protocols
• Optional:
  Experience in cell culture

• Success-driven
• Pro‑active
• Ability to work as part of a team

• Contract duration
  :
  Technical and scientific activities contract linked to the project (estimated duration until 31.8.2027)
• Estimated annual gross salary
  :
  Salary is commensurate with qualifications and consistent with our pay scales.

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