Senior or Principal Scientist of Human Genetics

The Position

About us:

Computational Innovation @ Boehringer Ingelheim

Boehringer Ingelheim is seeking a talented and experienced Senior or Principal Scientist in Human Genetics to join the Disease Genetics team within Global Human Genetics in Biberach. The role will focus on our cardio-renal-metabolic (CRM) portfolio and help translate population-scale genetic evidence into decisions across discovery and development.

The ideal candidate combines deep CRM disease biology with strong statistical genetics expertise and extensive experience analysing biobank-scale, clinical, and longitudinal datasets. You will use human genetics to identify and prioritise therapeutic concepts, clarify mechanisms of action, support indication strategy, and develop translational and patient-stratification hypotheses.

You have demonstrated success applying genetics in an industrial or translational research setting. You are comfortable integrating common- and rare-variant evidence with multidimensional datasets, including GWAS, QTL, omics, clinical phenotypes, and real-world or longitudinal data.

You are a driven, collaborative scientist who can move from rigorous analysis to a clear recommendation. Your insights and scientific leadership will directly influence target, indication, safety, and biomarker decisions across the CRM portfolio.

Discover our Biberach site:

This position can be filled either as Senior Scientist or Principal Scientist.
This position has a hybrid setup with approximately 2-3 days per week on site.
This position is part time eligible with 80 %.

• In your new role, you will drive human-genetics support for CRM discovery and portfolio projects, using population-scale biobanks, clinical cohorts, summary statistics, and longitudinal data to generate decision-relevant evidence.
• You will identify and prioritize genetically supported targets and indications, and deliver robust genetics packages for key portfolio milestones, including Candidate Selection
• Furthermore, you will apply state-of-the-art methods including GWAS and PheWAS, fine-mapping, colocalisation, Mendelian randomisation, rare-variant analysis, polygenic risk scores, and time-to-event analysis.
• You will integrate genetic evidence with molecular QTL, transcriptomic, proteomic, single-cell, and other functional data to characterise causal genes, cell types, mechanisms, and disease subtypes.
• Moreover, you will translate findings into clear recommendations for therapeutic concept, mechanism-of-action, indication, safety, and prognostic or predictive biomarker decisions.
• You will partner closely with CRM therapeutic area, experimental, clinical, translational, data engineering, and computational colleagues in a matrix environment.
• In addition, you will lead cross-functional Human Genetics initiatives, communicate complex evidence to senior stakeholders, and establish strategic external collaborations to strengthen CRM genetics data, methodologies, disease expertise, and shared standards, workflows, and products.

• As Principal Scientist, you will independently define and drive the human-genetics approaches for complex CRM portfolio questions, translating strategic priorities into an integrated plan with limited day-to-day direction.
• You will own the most complex and ambiguous genetics work streams from problem framing through portfolio decision, integrating evidence across targets, indications, mechanisms, biomarkers, and safety while managing scientific trade-offs.
• Furthermore, you will act as a senior scientific authority for Human Genetics in cross-functional governance and portfolio forums, influencing senior stakeholders and representing the function in high-impact internal…