Senior- Director Clinical Development - Late Stage & ADC Oncology

Munich, Germany;
London, United Kingdom;
Mainz, Germany | full time | Job

As a (Senior) Director of Clinical Development at BioNTech, you will collaborate closely with the VP of Clinical Development to drive innovative strategies for assigned programs. In this pivotal role, you will oversee the design and execution of clinical trials across all phases, ensuring data integrity, patient safety, and regulatory approval. Leveraging your deep expertise in Immuno-Oncology and Oncology, you will lead matrix teams to deliver impactful results while guiding decisions with scientific rigor and medical insight.

Join us to shape the future of medicine through cutting-edge research and development.

• Lead clinical trial design to develop plans for new compounds from early exploratory studies through late-stage development and regulatory approval.
• Collaborate with the VP to operationalize clinical strategies for assigned portfolios and ensure alignment across functions.
• Serve as Program Lead, guiding core teams, driving program strategy, and preparing submission processes.
• Ensure patient safety by overseeing medical aspects of studies, conducting risk-benefit assessments, and addressing medical queries.
• Innovate in trial design, leveraging digital endpoints and real-world evidence to enhance study outcomes.
• Develop key clinical documents, including Investigator’s Brochures, NDAs, and high-quality Clinical Study Reports.
• Build strong relationships with external stakeholders while representing the team in governance meetings.

• M.D. degree with a robust scientific and clinical background in Immuno-Oncology or Oncology.
• Extensive experience leading clinical development programs across Phases I–III, including NDA submissions.
• Expertise in advanced clinical study designs, companion diagnostics for patient selection, translational modeling, biostatistics, and confirmatory Phase III trial design.
• Proven experience interacting globally with health authorities (e.g., EMA, FDA), with successful registration being advantageous.
• Strong medical acumen in monitoring safety/efficacy data and managing patient-centric drug development processes.
• Exceptional leadership skills to mentor teams while accelerating capabilities through situational management styles.
  BioNTech offers a collaborative environment where innovation meets purpose. If you are passionate about advancing therapies that make a difference in patients' lives, we invite you to join our mission-driven team.

Expected Pay Range: $168,100-$318,300 plus benefits, annual bonus & equity (bonus and equity is variable and dependent on company and individual performance).
* Compensation for the role will depend on several factors, including responsibilities of the job, education, experience, knowledge, skills, and abilities.

It's our priority to support you:

• Your flexibility: flexible hours |vacation account
• Your growth:
  Digital Learning | Performance & talent development | leadership development | Apprenticeships | Linked In Learning
• Your value:
  Your voice at the table | Culture on an equal footing | Opportunities to shape & impact | Support for your full potential
• Your health and lifestyle:
  Company bike
• Your mobility:
  Job ticket | Deutschlandticket
• Your life phases:
  Employer-funded pension | Childcare

Job (please always specify if you have any questions)

By submitting your application, you acknowledge that a background check will be conducted as part of the recruitment process in accordance with applicable laws and regulations. If you are considered for the position, BioNTech will conduct the background check through our service provider ‘Hire Right’. You will be informed accordingly by your BioNTech-Recruiter.