Postdoctoral Researcher; m​/f​/d - Strategies Targeting Autoreactive Plasma Cells; Team TAP

Postdoctoral Researcher (m/f/d) – New Strategies for Targeting Autoreactive Plasma Cells (Team TAP)

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Bio Med X is an independent research institute located on the campus of the University of Heidelberg in Germany, New Haven in Connecticut, XSeed Labs in Ridgefield, Connecticut, and a worldwide network of partner locations. Together with our partners, we identify big biomedical research challenges and provide creative solutions by combining global crowd sourcing with local incubation of the world’s brightest early‑career research talents.

Each of the highly diverse research teams at Bio Med X has access to state‑of‑the‑art research infrastructure and is continuously guided by experienced mentors from academia and industry. At Bio Med X, we combine the best of two worlds – academia and industry – and enable breakthrough innovation by making biomedical research more efficient, more agile, and more fun.

The group ’New Strategies for Targeting Autoreactive Plasma Cells (TAP)’, led by Dr. Eleonora Melzi, focuses on understanding the development and persistence of autoreactive plasma cells and the production of pathogenic autoantibodies. By employing a combination of state‑of‑the‑art single‑cell transcriptomic and high‑throughput antibody analysis, we aim to identify new biomarkers of B cell autoreactivity. Ultimately, our goal is to define novel therapeutic strategies specifically targeting autoreactive plasma cells, thus advancing the diagnosis, treatment, and prevention of autoimmune diseases.

We are seeking a highly motivated, detail‑oriented Postdoctoral Researcher to join Team TAP and contribute to projects focused on the characterization of autoreactive B cells and plasma cells in neurological diseases. The ideal candidate thrives in a fast‑paced, collaborative research environment, enjoys tackling complex biological questions, and can work independently while actively contributing to team discussions. The successful candidate will take scientific ownership of defined projects, including experimental design, data analysis, and interpretation, and will be expected to present scientific results internally and at national and international conferences, as well as contribute to the writing of manuscripts for publication.

This position offers the opportunity to work at the interface of basic immunology, cutting‑edge technology, and translational research.

• PhD in Immunology, Molecular Biology, or related field.
• Demonstrated interest in B cell biology, antibody responses, and immune‑mediated disease.
• Hands‑on experience with human samples, including cell culture and lymphocyte isolation.
• Strong expertise in flow cytometry, including multi‑color panel design, data analysis, and cell sorting.
• Experience with core immunological assays such as ELISA and ELISpot.
• Solid understanding of cell and tissue biology.
• Ability to work independently, think critically, and manage multiple experimental workflows.
• Experience working in diverse and interdisciplinary teams (including immunologists, clinicians and industry partners).
• Excellent communication skills in English, both oral and written.
• In‑depth background in B cell and plasma cell immunology.
• Experience with single‑cell technologies (e.g. scRNA‑seq, CITE‑seq, immune repertoire analysis).
• Familiarity with high‑dimensional data analysis and experimental design for complex datasets.

• A one‑page cover letter explaining their interest in joining Team TAP.
• A CV highlighting scientific interests, research experience, and publications.
• Two reference letters or contact details of two referees.

• The position is sponsored by SERVIER and is available immediately.
• The position is offered initially for three years with the possibility of extension.
• Flexible working hours and hybrid working location.
• Access to a vast…