Scientific Software Developer II – Modeler

Scientific Software Developer II – Modeler page is loaded## Scientific Software Developer II – Modeler locations:
SANTA FE 01:
BOSTON 01time type:
Full time posted on:
Posted Todaytime left to apply:
End Date:
December 31, 2026 (30+ days left to apply) job requisition :
R53423##
** At Cadence, we hire and develop leaders and innovators who want to make an impact on the world of technology.
**** Open Eye, Cadence Molecular Sciences** – a division of Cadence Design Systems – is an industry leader in computational molecular design through rapid, robust, and scalable software, consulting services, and Orion(R), the only cloud-native fully integrated software-as-a-service molecular modeling platform. Combining unlimited computation and storage with powerful tools for data sharing, visualization and analysis in a customizable development platform, Orion offers unprecedented capabilities for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances.

Open Eye, Cadence Molecular Sciences is headquartered in Santa Fe, N.M., with offices in Boston, Mass.;
Cologne, Germany; and Tokyo, Japan.

We are looking for a Computational Chemist/Cheminformatician to join our team of experts in mathematics, computational modeling, and medicinal chemistry.  This highly focused team will work together to drive forward technology which leverages Open Eye’s Orion platform to better enable scientists in the pharmaceutical industry working on projects from lead development to clinical candidate selection.  This role will require interactions with customers and Open Eye’s scientific and technical teams.
*
* What you’ll do:

*** Extend Open Eye’s programming toolkits by developing and implementing new and useful scientific and technical features to aid customers in developing bespoke solutions.
* Explore methods for further enhancing Open Eye’s virtual screening platform (including OMEGA, ROCS, FastROCS, OEDocking).
* Apply chemistry/cheminformatics expertise with ML experts to build robust, scalable models to support data-driven decision making.
* Work on retrospective and prospective projects both internally and with collaborators to validate methodologies.
* Work with Orion project team to further optimize compound design workflows in Orion.
** What you should have:
*** PhD (or equivalent experience) in computational chemistry, chemistry, cheminformatics, or related field with 0 – 3 years relevant experience
* Knowledge of some traditional computational chemistry approaches such as docking, virtual screening, molecular modeling, etc.
* Programming expertise, ideally in c++ and/or python preferably with experience using AI coding agents
* Experience in or desire to learn about the pharmaceutical industry
* Strong desire to find practical solutions to challenging problems
* Demonstrated ability to work both as part of a team and independently
** The following are a PLUS, but not required:
*** Experience with Open Eye software/toolkits
* Expertise with diffusion models, transformers or 3D ML representations
* Experience with synthetically accessible, pharmaceutically relevant generative chemistry
** Benefits:
** We are passionate about the welfare of our employees and offer competitive benefits that include medical, dental, vision, flexible working schedule, 401k retirement plans, paid vacation, paid sick leave, home internet costs, public transportation reimbursement,  and much more.
*** Please submit your cover letter and resume as one document.
**** Open Eye Scientific Software is an Equal Opportunity Employer.*##
** We’re doing work that matters. Help us solve what others can’t.
**** Equal Employment Opportunity Policy:
** Cadence is committed to equal employment opportunity throughout all levels of the organization.

We welcome your interest in the company and want to make sure our job site is accessible to all. If you experience difficulty using this site or to request a reasonable accommodation, please contact
** Privacy Policy:
** Job Applicant If you are a job seeker creating a profile using our careers website, please see the .E-Verify Cadence participates in theE-Verify program in certain U.S. locations as required…