Sterile Value Stream Director

Job description

Site Name: UK - County Durham - Barnard Castle

Posted Date: Dec 18 2025

Posting Period: Until the 15th of January 2026

As Sterile Value Stream Director, you will be accountable for leading end‑to‑end sterile operations across the Barnard Castle value stream. You will define and deliver the strategic transformation required to move the site from foundational rebuild to scale and excellence, ensuring safe, compliant, and cost‑effective supply of sterile medicines to global markets. This is a visible, high‑impact, site based full time leadership role that requires experience in sterile manufacturing, strategic thinking, and proven capability to lead large scale change across people, processes, and technology.

A key element of the role is to create and sustain high performing management teams and to develop managers across the site who can embed and sustain operational excellence. The role covers a diverse range of product modalities including small and medium molecules, large molecules, monoclonal antibodies (mAbs), oligonucleotides and other advanced modalities.

• Strategic Leadership: Define and execute the sterile value stream strategy to deliver Barnard Castle's vision for transformation, growth, and excellence. Translate global strategy into pragmatic, measurable site level plans
• Unify Manufacturing Teams: Break down silos and build a single, integrated one team manufacturing organisation across sterile operations, fostering alignment, shared accountability, and consistent execution across all manufacturing leaders
• Create High Performing Management Teams: Build, coach, and hold accountable a strong leadership team capable of delivering site objectives. Establish clear leadership structures, roles, and decision rights; set expectations and development plans; and ensure leaders model desired behaviours and drive performance
• Develop Leaders and Succession Plans: Implement leadership development programmes, mentorship and coaching frameworks, and succession planning to ensure bench strength and continuity. Promote a culture of compliance, continuous learning and leadership capability building at all levels
• Drive Change and Transformation: Lead change management programmes to rebuild foundational systems, embed new ways of working, and accelerate performance improvement. Sponsor and sustain lean/CI initiatives across sterile operations
• Digitalisation and AI Strategy: Shape and lead adoption of digital and AI enabled solutions to improve data driven decision making, predictive maintenance, process control, and workforce capability for future ready manufacturing
• Operational Delivery & Process Optimization: Oversee end to end sterile value stream processes including aseptic and terminal sterilisation, robotic filling, nano milling, and cold chain processing. Champion and drive productivity, yield, and throughput improvements using advanced technologies, ensuring approaches are appropriate to each modality (e.g., mAbs and oligonucleotides require specific cold chain, material handling and contamination control strategies)
• Quality, Compliance & Safety Accountability: Take ownership for product quality and regulatory compliance across sterile operations. Embed a safety‑first culture and ensure robust systems and behaviours that meet GSK and global regulatory standards, including modality specific regulatory expectations for biologics, mAbs and oligonucleotides
• Performance Monitoring: Define and track KPIs across people, safety, efficiency, quality, cost, and delivery. Use data and insights to drive corrective actions, continuous improvement, and measurable outcomes
• Resource Allocation & Financial Stewardship: Prioritise and optimise allocation of materials, people, and equipment to meet production goals while controlling operational cost and capital investments
• Technology Optimization: Maximise value from technologies such as robotic filling, single use systems, HVLD and vacuum decay leak detection, inspection automation, RABS/CIP SIP systems, nano milling, and integrated eBRS systems. Ensure technology choices and validation…