Portfolio & Program Management Director

Position Summary

The Director of Portfolio and Program Management (PPM) sits within the COO organization and provides strategic and operational leadership across a portfolio of cross-functional Research programs and projects, spanning early research through candidate preclinical development. The role is accountable for both portfolio-level oversight and direct program management, ensuring alignment with research priorities and delivery against organizational objectives. Working in close partnership with the Cell and Gene Therapies (CGT) Site Head, Chief of Staff, Program Leaders, and cross-functional stakeholders, the Director provides integrated portfolio insights, enables prioritization, drives strategic decision-making, and ensures execution of critical site and program objectives.

As a key leader within Research PPM, the Director promotes high-performing, data-driven ways of working, strengthens portfolio governance and visibility, and serves as a trusted thought partner to research leadership. The role also includes line management responsibilities and contributes to the development of PPM capabilities, talent, and organizational effectiveness.

• Partner with Program Leaders to lead portfolio planning, drive strategic decision-making, and ensure effective execution across research and early development programs.
• Lead and oversee a portfolio of Research programs and projects from early research through candidate preclinical development, ensuring alignment to organizational and corporate priorities.
• Directly lead priority cross-functional projects and programs, driving planning, execution, decision-making, and delivery against key milestones and goals.
• Partner closely with the CGT Site Head and Chief of Staff to provide clear, accurate, and timely portfolio and program updates, including status, risks, milestones, resource needs, and decision points, while helping ensure delivery of site objectives.
• Guide cross-functional R&D teams to establish high-performing, data-driven ways of working that deliver on corporate objectives and priorities.
• Lead the approach for cross-functional decision-making and issue resolution, identifying key stakeholders and driving alignment on priorities, governance, and actions.
• Develop and maintain integrated portfolio and project timelines and reporting, defining critical path activities, interdependencies, and potential bottlenecks.
• Proactively identify, assess, mitigate, and escalate risks, gaps, challenges, and roadblocks that could impact program or site delivery.
• Lead the generation of program assumptions for annual resource allocation and budgeting across Research and Development functions.
• Identify, communicate, and manage resource constraints, synergies, and redundancies across the portfolio.
• Effectively manage key meetings, stakeholder communications, action items, decisions, and follow-through to support execution and accountability.
• Communicate complex topics to stakeholders through effective storytelling and content creation.
• Establish team operating norms and identify opportunities to improve team and portfolio performance.
• Work with Portfolio and Program leadership to build, manage, coach, and retain PM staff.
• Serve as a key PPM leader, translating site goals into actionable portfolio and project plans.

• Demonstrated ability to lead a portfolio of complex projects in a fast-paced Research environment.
• Strong ability to partner with senior site leadership to translate strategic priorities into executable plans.
• Proven ability to drive accountability and delivery across matrixed cross-functional teams.
• Comprehensive knowledge of project and portfolio management principles, best practices, tools, technology and methods.
• Leadership experience managing cross-functional teams.
• Excellent written and oral communication skills, including well-developed presentation skills.
• Comprehensive pharmaceutical drug discovery and development knowledge across multiple disciplines.
• Exceptional organizational skills and an ability to manage multiple priorities.
• Strong collaboration skills to effectively interact with internal or external stakeholders at all levels of the organization.
• Ability to work in a fast-paced and collaborative environment and manage multiple concurrent projects with a high degree of independence.
• Experience in carrying out Risk Analysis, Decision Analysis and Contingency Planning.
• A desire to be part of a highly innovative company…