R&D Scientist Enzyme Engineering

Position

R&D Scientist Enzyme Engineering at Watchmaker Genomics

Cape Town, South Africa (onsite)

Full-Time Employee

PhD in Molecular Biology, Biochemistry, or related discipline; 0-5 years experience.

We are seeking a motivated and detail-oriented R&D Scientist to join our Research and Development team in Cape Town, South Africa. This role reports to the Enzyme Engineering Team Lead and will support a research program dedicated to developing novel proprietary technologies used for various proteomics and molecular diagnostics applications. The successful candidate will thrive in a dynamic, fast-paced environment and contribute positively to our company culture and success.

This position offers an opportunity to participate in the development of novel technologies that create value for customers in the life sciences and clinical diagnostics markets. In this role, you will work closely with our Computational Biology department.

• Design, plan, and perform molecular biology experiments, including plasmid vector design and construction.
• Plan and perform protein purification experiments including cell lysis, cell‑free protein synthesis, small‑scale affinity purification, and FPLC‑assisted affinity purification.
• Develop, troubleshoot, and optimize molecular biology assays systematically.
• Plan and perform molecular biology experiments including PCR, qPCR and preparation of NGS libraries.
• Accurately document details of all experiments in an electronic lab notebook; meticulously analyze and interpret data; and regularly present results and project status updates to managers and peers for discussion.
• Contribute to conceptualizing and inventing technologies for the genomics and molecular diagnostics markets.

• Proficiency in molecular biology techniques, including cloning, PCR, qPCR and primer design.
• Experience in setting up and troubleshooting enzyme assays.
• Experience in NGS data analysis would be an advantage.
• Specific knowledge of DNA- and RNA-modifying enzymes.
• Strong interest in protein biochemistry and molecular biology.
• Proteomics knowledge and experience (Soma Scan, Olink) would be an advantage.
• Demonstrated ability to plan, execute, troubleshoot, and interpret high‑quality experiments.
• Excellent organizational skills with meticulous attention to detail.
• Strong interpersonal and communication skills, with the ability to work effectively both independently and as part of a team.
• High level of self‑motivation and initiative, with the ability to multitask and perform consistently under pressure.
• A creative and disciplined approach to problem‑solving.
• Excellent written and verbal communication skills.

• MSc in biochemistry, molecular biology, biochemistry or a related discipline + 3 years of relevant experience; or
• PhD in molecular biology, biochemistry or a related discipline.

• Letter of motivation (submit where indicated for cover letter).
• Resume or Curriculum Vitae, highlighting relevant qualifications and experience.

Applications without a Letter of Motivation will not be considered. Applicants must be South African or be eligible to work in South Africa and already possess the necessary work permits or visas, or be able to obtain them before responding to this vacancy.

Submit your application by Sunday, 18 January 2026. This position may close earlier if we receive a high volume of applications. We encourage you to apply as soon as possible.

If selected to participate in the interview process, the names and contact information of three professional references who can assess your suitability for the position will be requested. We will also request a current payslip.

NO RECRUITMENT AGENCIES PLEASE We are only accepting direct applications for this position. We are not working with external recruiters or agencies at this time. Unsolicited resumes or candidate submissions from third‑party recruiters will not be considered and will be deemed the property of Watchmaker Genomics.

SOUTH AFRICA - WE ARE AN EQUAL OPPORTUNITY/AFFIRMATIVE ACTION EMPLOYER Watchmaker Genomics is committed to being an…