Senior Biostatistician

All U.S. Locations (remote); candidates must reside in the United States.

The Senior Biostatistician is Pace Mate's first biostatistician. The role independently leads the statistical design, analysis, and reporting of Pace Mate's clinical research, including internal quality and research studies and externally published work.

The role owns each study from analysis plan through peer-reviewed publication and response to reviewers, working directly with the Chief Medical Officer and Pace Mate's clinical team. About a quarter to a third of the role applies the same methods to operational and business questions. Routine operational reporting and dashboards sit outside this role. AI-assisted tools are part of how this role works every day, and the role is accountable for validating every result they help produce.

The position has latitude to shape its own workflow and a potential path to expanded oversight of research-related functions.

• Write and execute statistical analysis plans for retrospective and real-world evidence studies, including target trial emulation. Define estimands (ICH E9(R1)), cohorts, exposure windows, and outcomes with the Chief Medical Officer and clinical investigators.
• Link and validate multi-table device data. Confirm denominators, person-time, and follow-up, and address left truncation and immortal time bias around device implant and remote monitoring enrollment.
• Analyze count and rate outcomes (Poisson and negative binomial regression with person-time offsets), recurrent events (Andersen-Gill, PWP, and frailty models; mean cumulative function), time-to-event outcomes with competing risks (cause-specific hazards, Fine-Gray, Aalen-Johansen), and clustered data (mixed-effects models, GEE).
• Control confounding with propensity score methods (IPTW, overlap weights, matching). Handle informative censoring with IPCW and missing data with multiple imputation. Test robustness with E-values, negative control outcomes, and tipping-point analyses.
• Write and review methods and results sections for abstracts and peer-reviewed manuscripts to STROBE and RECORD standards. Respond to co-author and external advisor critique.
• Respond to peer review: re-analyses, statistical sections of response letters, and defensible positions under methodological critique.
• Evaluate operational and business changes using interrupted time series, segmented regression, difference-in-differences, and statistical process control. Present effect estimates with confidence intervals to leadership in plain language.
• Use AI coding assistants (e.g., Git Hub Copilot, Claude, ChatGPT) daily to write, review, debug, and document R and SQL code and analysis reports. Validate all generated code and results before use, and use only Pace Mate-approved tools with protected health information.
• Provide statistical input and limited analyses to support quality improvement, patient safety monitoring, and clinical operations when needed. This is not a primary QA role.
• Build reusable research infrastructure with the data science team: standardized cohort definitions, reusable R code, and templated outputs.
• Maintain the analytic queue and the documentation that lets any published result be reproduced by script from the raw data extract.
• Maintain high level understanding of Pace Mate products and services.
• Maintain appropriate levels of current knowledge and the ability to interpret, comprehend, and apply policies. Assist in ensuring consistency in practices and Pace Mate Mission, Vision, and Customer Service standards are met. Adhere to the Code of Conduct and all Company Policies and Procedures.

• Infrequently, prepare IRB…