PhD Student Disc And Cartilage Biology Studentjob.ch

PhD Student Disc And Cartilage Biology (ID1891)

The AO is a medically guided, not-for-profit organization, a global network of surgeons, and the world's leading education, innovation, and research organization specializing in the surgical treatment of trauma and musculoskeletal disorders. We are home to people from all over the world, from different backgrounds, with diverse talents and specialist areas. What binds us together is our passion for excellence, our dedication to our mission of improving patient care, and our understanding that we are stronger together: we are one AO.

Short Description

ARI's Regenerative Orthopaedics program is a multidisciplinary team taking a holistic approach to regenerative medicine for the repair of musculoskeletal injuries and degeneration. We combine specialist knowledge in cell and molecular biology, microbiology, polymer chemistry, and bioengineering to investigate cell-material interactions in vitro, ex vivo, and in vivo. We are highly experienced in the development of ex vivo organ models and complex bioreactor systems that are used to apply physiological load and reduce the number of animal studies required in accordance with 3R principles.

The objectives of this consortium project funded by the Swiss National Science Foundation are the fabrication of a full intervertebral disc model using cells and biomaterials, the implementation of degenerative conditions and mechanical loading, and the validation of the system through interaction with immune cells and anti-inflammatory compounds.

The doctoral candidate will work at the AO Research Institute Davos and focus on the fabrication of a mechanically loaded cell seeded intervertebral disc model. You will be working with various 3D bio‑printed intervertebral disc models, consisting of nucleus pulposus, annulus fibrosus and endplate parts. The constructs will be fit into uniaxial and multiaxial bioreactor systems and cultured under mechanical loading with or without a pro‑inflammatory component.

You will be involved in every aspect of design, application, and validation of innovative preclinical models that will help to understand mechanisms of disc degeneration and to test new therapies for patients suffering from discogenic low back pain. Towards this aim, you will closely collaborate with a second doctoral student working on the same project, and with our French project partners from Nantes University and Sorbonne University.

As mentioned above, this project is supported by the Swiss National Science Foundation, which is also supporting another PhD student position in the same institute on the topic of 3D bioprinting and immunomodulatory biomaterials. There will be close collaboration between these 2 PhD students.

• Background in biomedical sciences with an interest in tissue engineering; collaboration in a multidisciplinary team comprising fundamental and clinical scientists from many specialties, including biology, chemistry, biomechanics, and modelling.
• MSc degree with excellent marks and experience in the field of cell biology, biochemistry, or bioengineering.
• Practical experience in cell/tissue culture.
• Experience in biochemical and molecular biological analysis techniques.
• Enthusiasm for regenerative medicine with excellent written and oral communication skills.
• Membership in the Disc and Cartilage Biology Focus Area within the Regenerative Orthopaedics Program, with access to excellent facilities and experienced translational research teams.
• Enrollment in a PhD Programme within the D‑HEST of ETH Zürich, with access to a variety of post‑graduate training.
• Good English language skills and a suitable work ethic.
• Familiarity with a cross‑cultural/interdisciplinary environment (advantage).
• Eligibility to apply and obtain a Visa for temporary residence in Switzerland.
• The starting date is 1 June 2026 and the duration of the role is 4 years.

• An interesting and varied job in an exciting and innovative organization.
• The opportunity to be part of a highly committed international team.
• Modern infrastructure.
• High degree of flexibility regarding working hours and location (depending on operational requirements).
• Generous package of social benefits, including supplementary vacation days and pension scheme contributions.
• Internal skills training opportunities and support for continued education.