Analytical Scientist; Biotechnology​/LNP & Lipid Analytics

Analytical Scientist (Biotechnology / LNP & Lipid Analytics)

Neo Vac is building a new groundbreaking LNP platform to deliver better mRNA vaccines and treatments for various diseases. At Neo Vac, we envision a world where mRNA vaccines and treatments are available to everyone and everywhere.

A new opportunity has arisen for a full‑time permanent Analytical Scientist. In this role, you will be responsible for the development, optimisation, and validation of analytical methods to characterise lipids, PEG‑polymers, nanoparticle components, process intermediates, and final drug substances.

You will work closely with formulation chemistry, RNA teams, and manufacturing partners to support drug development from discovery through early GMP stages. This role requires strong laboratory autonomy, problem‑solving capabilities, and a passion for high‑quality data.

• Develop, optimise, and validate analytical methods for lipids, polymers, and nanoparticle components using HPLC‑CAD, HPLC‑UV, LC‑MS.
• Perform structural and compositional profiling of PEG‑lipids, ionisable lipids, and excipients.
• Execute method validation according to ICH Q2 and support transition into cGMP workflows.
• Conduct routine and non‑routine analyses: assay, related impurities, stability studies and Endotoxin analysis.
• Independently troubleshoot analytical methods and instruments.
• Interpret data, prepare reports, and present results to cross‑functional teams.
• Support external CROs, CDMOs, and GMP partners as needed.
• Contribute to building analytical capability in a growing biotech environment, including SOPs, workflows, and instrument best practices.

• Master’s degree (MSc or higher) in Chemistry, Analytical Chemistry, Pharmaceutical Sciences or related field.
• 3+ years hands‑on experience with HPLC in industry (pharma/biotech preferred).
• Proficiency with HPLC‑CAD (strongly preferred).
• Hands‑on experience with LC‑MS for lipid or polymer analysis.
• Proven track record of method development (minimum 3–5 methods).
• Experience with cGMP method validation (at least 2 methods independently validated).
• Prior experience working in a GMP or cGMP analytical lab.
• Strong practical skills, autonomy, and troubleshooting abilities.
• Excellent documentation practices; familiarity with ICH Q2, Q14, and relevant regulatory guidelines.
• Ability to thrive in a fast‑paced, collaborative start‑up environment.

• Experience with lipid nanoparticles (LNPs), PEG‑lipids, polymers, or novel excipients.
• Experience with charged aerosol detection optimisation.
• Knowledge of DSC, Capillary Electrophoresis (CE), and Bacterial Endotoxin analysis.
• Familiarity with raw material qualification and release testing.

Mid‑Senior level

Full‑time

Didcot, England, United Kingdom