Job Description & How to Apply Below
Senior Research Scientist :
Synthesis R&D
Purpose of the Role:
To contribute to early-stage drug discovery programs by designing and synthesizing novel small molecules that meet client objectives. The role supports hit-to-lead and lead optimization efforts through data-driven medicinal chemistry strategies, with the goal of delivering high-quality drug candidates in a collaborative CRO environment.
Key Responsibilities:
Strategic & Scientific:
Design and synthesize novel chemical entities (NCEs) guided by SAR and target profile.
Contribute to lead identification and optimization in FTE or integrated drug discovery (IDD) projects.
Collaborate with cross-functional teams (e.g., biology, ADME, computational chemistry) to advance candidate selection.
Analyze biological and ADME data to refine compound design strategies.
Operational:
Plan and execute multistep organic syntheses with minimal supervision.
Characterize compounds using NMR, LCMS, HPLC, and other analytical tools.
Maintain detailed and accurate experimental records (ELN/lab notebooks).
Deliver high-purity compounds on time to meet client/project goals.
Collaboration & Communication:
Actively participate in team meetings, project reviews, and client discussions.
Coordinate with analytical and biology teams for data turnaround and integration.
Present experimental results and SAR insights to internal and external stakeholders.
Compliance & Documentation:
Follow lab safety protocols and maintain GLP/GMP (where applicable).
Ensure adherence to SOPs and maintain project documentation for IP protection and client reporting.
Qualification &
Experience:
M.Sc. with 3–8 years of relevant experience in a CRO environment.
Proven expertise in synthetic organic chemistry and medicinal chemistry principles.
Experience in client-facing discovery projects is strongly preferred.
Key Skills &
Competencies:
Deep understanding of SAR, pharmacophores, and drug-likeness criteria.
Strong skills in synthetic planning, reaction optimization, and troubleshooting.
Excellent communication and data presentation abilities.
Ability to multitask and work effectively in a high-paced, collaborative environment.
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