Research Associate II​/Senior Research Associate, IHC Biomarker Development

Syst Immune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). Syst Immune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. Syst Immune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

We are seeking a highly organized and detail-oriented Research Associate II or Senior Research Associate to support the development, optimization, and validation of immunohistochemistry (IHC) assays. This role will contribute to early-stage biomarker in support of clinical trial programs.

The ideal candidate will have 2–3 years of hands-on industry experience in histology, IHC, or a regulated laboratory environment (e.g., CLIA/CAP, GLP). This is a bench-focused position requiring close collaboration with scientists, pathologists, and cross-functional project teams.

This is full-time onsite at our Bothell, WA facility.

Responsibilities Histology

• Perform tissue sectioning of FFPE blocks.
• Route and support H&E staining workflows.

IHC Assay Execution

• Perform routine IHC staining on FFPE tissue specimens using automated platforms (e.g., Ventana, Leica).
• Conduct antibody titrations, protocol optimization, slide preparation, and quality control checks.
• Assist in generating feasibility, optimization, and analytical validation data for emerging CDx assays.
• Experience with Akoya Pheno Imager HT platforms is preferred.

Sample & Workflow Support

• Manage tissue samples and associated documentation.
• Prepare tissue sections, including slide cutting, baking, antigen retrieval, and reagent preparation.
• Maintain sample integrity, traceability, and documentation in compliance with quality system requirements.
• Support tissue handling workflows (blocks, slides, labeling, storage) within GLP or CLIA/CAP environments.

Data Collection & Documentation

• Accurately record experimental data in ELN and/or LIMS systems.
• Capture high-quality slide images and perform basic image analysis.
• Assist with slide scoring preparation and data summaries.
• Summarize experimental findings for internal meetings and assay development reviews.

Instrument & Laboratory Maintenance

• Operate, calibrate, and troubleshoot automated IHC staining platforms and related laboratory equipment.
• Perform routine instrument maintenance and maintain equipment logs per laboratory quality systems.
• Monitor and manage inventory of reagents, antibodies, controls, and consumables.

Cross-functional Support

• Collaborate with scientists, pathologists, QA, and clinical development teams on assay transfer, optimization, and validation activities.
• Support preparation of study materials, controlled documents, and protocol execution for validation studies.

Qualifications

• BS or MS in Biology, Molecular Biology, Pathology, Biomedical Sciences, or a related field.
  • Research Associate II requires bachelor’s degree and 2+ years of industry experience.
  • Senior Research Associate requires bachelor’s degree with 5+ years or master’s degree with 3+ years of industry experience.
• 2–3 years of hands-on experience in histology and/or IHC assay execution within a research or regulated diagnostic laboratory.
• Experience handling FFPE tissues and operating automated IHC staining platforms.
• Strong attention to detail with excellent documentation and record-keeping practices.
• Ab…