Research Scientist – Protein Mass Spectrometry

Overview

From target to the clinic. AbCellera’s platform integrates biology, computation, and engineering to develop impactful antibody-based medicines. We’re scientists, engineers, and business professionals who work together to turn scientific insights into breakthrough medicines. We pursue truth and scientific rigor. We think independently, act with conviction, and have the courage to work at the edge of the unknown. We offer the opportunity to stretch and explore, and to work on things that matter.

We are looking for a highly motivated scientist with demonstrated hands-on experience using mass spectrometry and other analytical techniques to join our team. You will focus on the characterization of antibodies and/or other therapeutic proteins, while working in a fast-paced, collaborative environment, interacting with a diverse team of scientists.

• Developing, designing, and qualifying bioanalytical LC/MS and CE/MS methods for qualitative and quantitative analysis of antibodies and other proteins
• Performing detailed protein structural interrogation, including sequence confirmation, sequence variant identification, disulfide mapping, or chemical modifications in support of batch comparison, forced degradation and develop ability analysis
• Developing and performing analytical assays for protein characterization such as ultra high performance liquid chromatography (UHPLC), light scattering (SEC-MALS, DLS), capillary electrophoresis (CE-SDS), or imaged capillary isoelectric focusing (icIEF)
• Training and mentoring members of our team
• Liaising with partners and communicating project updates and deliverables
• Developing and implementing standard operating procedures
• Organizing, supporting, and collaborating with team members to meet project deliverables and timelines

• You have hands-on experience with mass spectrometry, intact mass analysis, peptide mapping, and PTM analysis; experience with high resolution mass spectrometry, glycan mapping, disulfide mapping, cross-linking MS, HDX-MS, or other related methods would be an asset
• You are able to implement methods for high throughput sample preparation and automated data analysis, and have experience in method qualifications and drafting SOPs
• You have a PhD in Analytical Chemistry, Biochemistry, or a related field, or a have a MSc with 5+ years of relevant wet lab experience in an academic or industry setting
• You have experience with, or an interest in working with, other analytical techniques such as UHPLC, CE-SDS, SEC-MALLS, DLS, or icIEF
• You think critically, are curious, and want to explore new technologies and opportunities to improve antibody characterization workflows and processes
• You are a creative problem solver and fast learner who believes in team work to tackle the most challenging scientific problems
• You have great interpersonal skills, and thrive in a collaborative working environment as a member of cross-functional team
• You have excellent documentation, organizational, and communication skills, impeccable attention to detail, and an ability to analyse and interpret large datasets

AbCellera’s hiring range for this role is CAD $75,800 - $94,700 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution.

You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you’ll find we prioritize teams and social groups to build community and connections across AbCellera.

AbCellera is a global company focused on delivering breakthrough medicines that alleviate suffering, extend lives, and improve health. Our platform includes fully integrated capabilities to create first-in-class and best-in-class antibody medicines, from discovery to clinical manufacturing.

We are using our technological advantage to develop programs across multiple indications including endocrine and metabolic conditions,…