Principal Research Associate - Protein Science

Principal Research Associate - Protein Science (f/m/d) Job Description About Athebio

Athebio AG is a biotechnology company pioneering drug discovery and protein engineering through its proprietary Athebody® platform. We develop next- generation biotherapeutics, including targeted delivery systems (e.g., LNP, AAV) and radiotherapeutics, in collaboration with leading biotech and pharmaceutical partners.

As a Principal Research Associate in the Protein Science team, you will play a key hands-on laboratory role to support therapeutic candidate profiling and the development of innovative protein-based biotherapeutics. You will contribute scientific expertise across protein characterization, assay development, and protein production while working in a dynamic and collaborative biotech environment.

• Perform hands-on laboratory work in protein characterization, assay development, and protein production.
• Conduct therapeutic candidate profiling using biochemical and biophysical techniques.
• Develop, execute, and optimize ELISA and BLI assays for protein characterization and functional analysis as well as additional analytical methods including SEC, IEX, HIC, and CD.
• Analyze, interpret, and document experimental data; prepare reports and present results to internal teams and external partners.
• Perform small-scale protein expression in
  
  E. coli and purification to support analytical and discovery workflows.
• Collaborate effectively across teams, maintain high scientific standards, and adapt efficiently to changing priorities.

• Degree in life sciences (e.g., biochemistry, protein science, biotechnology) or equivalent technician training, with ≥8 years of relevant professional experience
  ; industry experience is an advantage.
• Strong hands‑on experience in microbial protein production (especially
  
  E. coli at MTP scale),
  protein purification, and characterization using the methods listed above.
• Strong background in biotherapeutic discovery and candidate profiling.
• Ability to work independently and proactively in a fast-paced biotech environment.
• Excellent communication and collaboration skills.
• Proficiency in English, both written and spoken.

• An exciting opportunity to take responsibility and grow professionally and personally within an early-stage biotech company.
• The ability to actively contribute to and shape the development of the organization.
• Exposure to and collaboration with world-leading experts in DARPin® technology.
• A diverse and multifaceted role within a highly collaborative and innovative environment.

• Join us at our state-of-the- art facility in the Bio-Technopark Schlieren
  , Zurich.

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