Scientist III; In Vivo Studies

Scientist III (In Vivo Studies) page is loaded## Scientist III (In Vivo Studies) locations:
Alameda, CAtime type:
Full time posted on:
Posted 2 Days Agojob requisition :
JR6565
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* SUMMARY:

** The Scientist III will support multidisciplinary research teams by designing and executing preclinical in vivo studies in rodents.  The successful candidate will integrate pharmacokinetics with pharmacodynamics/efficacy and/or toxicology to provide assessments around drug exposure relationship to target-engagement/efficacy and/or tox signals.
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* ESSENTIAL DUTIES AND RESPONSIBILITIES:

*** Design and execute in vivo studies in both rat and mouse models and work with key stakeholders to provide interpretation around the pharmacokinetics, pharmacodynamics, efficacy, and toxicology of preclinical drug candidates.
* Coordinate with various functional groups, including PK, toxicology, pharmacology, formulation, and bioanalytical sciences, to ensure timely data delivery.
* Collaborate with various scientific functions within project teams to design in vivo studies to address hypotheses.
* Prepare and organize data for presentation using analysis and visualization software, present data and reports on project status at individual, group, and departmental research meetings.
* Maintain laboratory notebook in a complete, consistent, and concise manner following company intellectual property policies and practices.
* Adhere to good health and safety practices, comply with applicable EH&S rules, and participate in mandatory safety training programs.
* Collaborate with the IACUC committee to ensure compliance with internal policies and animal welfare regulations.
* Maintain familiarity with current scientific literature relevant to the research experiments or program.
* Foster a science-driven, goal-oriented culture that values innovation, teamwork, agility, transparency, accountability, and empowerment.
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* SUPERVISORY RESPONSIBILITIES:

*** None
* * EDUCATION/EXPERIENCE/

SKILLS:

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* Education:

*** BS degree in a related discipline and a minimum of three years of related industry experience; or,
* Master's degree in a related discipline and a minimum of one year of experience; or,
* Equivalent combination of education and experience.
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* Experience:

*** Proficient with in vivo techniques, including animal handling (mouse and rat), different dosing routes (IV, IP, SC, PO, IM, etc.), blood collection techniques (tail vein, RO, cardiac puncture, etc.), and tissue collection/necropsy in rat and mouse.
* In-depth experience with animal tumor model development and execution; including, but not limited to syngeneic, xenograft, PDX and humanized mouse models is required.
* Expertise in cell culture with aseptic technique and scale-up for tumor implantation is required
* Experience in pre-formulation for small molecules is a plus.
* Proven track record of good experimental design, in-depth data analysis, and interpretation based on strong scientific rationale.
** Knowledge/Skills/Abilities:
*** Strong knowledge and skills in working with rats and mice, as well as intimate knowledge of formulating in vivo study protocols, IACUC protocols, AAALAC guidelines, and vivarium techniques/best practices, are a must.
* In-depth knowledge of pharmacokinetics and/or toxicology and/or pharmacology is preferred.
* Works independently; self-motivated, innovative, and proactive in identifying and troubleshooting issues.
* Has flexibility to accommodate a fast-paced work environment and deadlines and the ability to work under specific time constraints.
* Strong communication skills, excellent work ethic, self-motivation, and ability to work effectively in a team environment or independently.
* Advanced knowledge of MS Office, PDF, Graph Pad, ELN notebook, and Studylog is required.
** JOB COMPLEXITY:
*** Work on problems of diverse scope where data analysis requires evaluating identifiable factors.
* Exercise judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions.
* Occasional weekend and holiday work will be required to support in vivo studies.#LI-HG1
* If you like wild growth and working with happy, enthusiastic…