Sr. Translational Pharmacology and Drug Development SETA

Overview Systems Planning and Analysis, Inc. (SPA) delivers high-impact, technical solutions to complex national security issues. With over 50 years of business expertise and consistent growth, we are known for continuous innovation for our government customers, in both the US and abroad. Our exceptionally talented team is highly collaborative in spirit and practice, producing Results that Matter. Come work with the best!

We offer opportunity, unique challenges, and clear-sighted commitment to the mission. SPA:
Objective. Responsive. Trusted.  The Joint, Office of the Secretary of Defense, Interagency Division provides expert support services to a range of customers spanning across the Department of Defense, Federal Civilian, and international markets. JOID provides a diverse portfolio of analytical and programmatic capabilities to help our customers make informed decisions on their most challenging issues.

SPA provides critical decision support to enabling and executing a strategy of technological superiority and enabling the delivery and sustainment of secure, resilient, and preeminent capabilities to the warfighter quickly and cost effectively. Our team of experienced military, technical, and operations research analysts is skilled in evaluating military problems, identifying the driving factors, devising innovative approaches, collecting applicable data, developing necessary software tools, and performing thorough and timely assessments to inform technology and acquisition governance decisions to ensure U.S. military forces retain military superiority in the future.

We have an immediate need for a Sr. Translational Pharmacology and Drug Development SETA with the ability to provide onsite support out of Arlington, VA.Responsibilities The candidate will provide scientific, technical, and program management support to DARPA program managers. The programs encompass molecular target discovery, medicinal chemistry, immunology, trauma biology, and translational drug development. Will work closely with a DARPA Program Manager and a multidisciplinary government support team to evaluate technical progress, identify risks, coordinate performers and stakeholders, and accelerate promising technologies toward clinical and operational use.

Provide independent scientific and technical analysis of research involving small-molecule screening, computational drug discovery, receptor pharmacology, structure-activity relationships, molecule transit across the blood-brain barrier, and medicinal chemistry optimization. This includes immunomodulatory peptides, extracellular vesicles, antimicrobial mechanisms, innate immunity, inflammation, and host-pathogen interactions, preclinical pharmacology, toxicology, efficacy, pharmacokinetics, pharmacodynamics, and therapeutic-index evaluation. Assess performer progress against technical, schedule, cost, and transition objectives.

Review experimental plans, study designs, protocols, data packages, statistical analyses, and performer reports for scientific rigor and relevance to program goals. Evaluate in vitro and in vivo models, including models of trauma, hemorrhage, burn injury, polytrauma, anesthesia, systemic infection, and sepsis. Perform additional scientific and programmatic analyses in support of the Program Manager’s portfolio as required.

Qualifications

Required:

Doctorate degree in pharmacology, molecular pharmacology, medicinal chemistry, pharmaceutical sciences, molecular or cellular biology, biochemistry, immunology, microbiology, neuroscience, toxicology, biomedical engineering, or a closely related discipline.
9+ years of relevant work experience.

Demonstrated expertise in translational pharmacology and therapeutic development.

Strong technical…