Specialist - DMPK Bioanalysis

Position: Specialist - DMPK Bioanalysis Role
Location: Bengaluru

Role :  Specialist - Bioanalysis (In Vitro DMPK)

Job Location :  Bengaluru

As a Specialist, you will be the technical expert for all in vitro bioanalytical activities, ensuring the accurate, timely, and efficient delivery of ADME data to support drug discovery and development projects.

Key Responsibilities:

LC-MS/MS Mastery:  Serve as the subject matter expert for the operation, maintenance, and advanced  troubleshooting  of LC-MS/MS instruments used for ADME sample analysis.
Bioanalytical Execution:  Plan, execute, and analyze a diverse range of  in vitro ADME Assays , including:
Permeability Studies:  Cell-based models (e.g., Caco-2, MDCK) and non-cell-based assays (PAMPA).
Metabolic Stability:  Assays such as Hepatocyte and Microsomal stability, and CYP-Inhibition.
Physicochemical & Stability:  High-throughput solubility, Plasma, Buffer, SGF, and SIF stability assessments.
Project Flow Optimization:  Maintain and  optimize the bioanalytical project workflow  to ensure efficient throughput and meet all study timelines.
Physicochemical Profiling:  Lead the execution of Kinetic solubility, Thermodynamic solubility, and Chromatographic  Log D  studies.
Metabolite Identification (MET-):  Analyze MET- and prepare detailed, comprehensive reports.
Team Leadership:  Act as a mentor, providing  hands-on training  and technical guidance to junior team members on various bioanalytical techniques and protocols.

Qualifications &

Experience:

Qualification:

M. Pharma

Experience:

8 to 15 years  of direct, relevant experience in bioanalysis, with a strong focus on  DMPK/ADME studies , preferably within a pharmaceutical or CRO setting.
Technical

Skills:

Must be highly proficient and well-versed in handling and executing bioanalytical assays using  LC-MS/MS technology .