Clinical Development Lead

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The purpose of Idorsia is to challenge accepted medical paradigms, answering the questions that matter most. To achieve this, we will discover, develop, and commercialize transformative medicines – either with in-house capabilities or together with partners – and evolve Idorsia into a leading biopharmaceutical company, with a strong scientific core.

Are you an experienced clinical development professional eager to take scientific ownership of a clinical program and help shape the future of a differentiated therapy?

We are seeking a scientifically curious, strategic and hands-on
Clinical Development Lead to provide clinical and scientific leadership across the design, execution and interpretation of clinical studies. In this role, you will play a central role in translating scientific insight into high-quality clinical evidence and development decisions that can make a meaningful difference for patients.

This role offers the opportunity to shape lifecycle evidence generation and unlock the full potential of differentiated medicines through clinically meaningful, scientifically robust and strategically aligned development activities.

Working closely with Clinical Operations, Regulatory Affairs, Drug Safety, Biostatistics, Medical Affairs and Commercial colleagues, you will ensure development plans are scientifically robust, operationally feasible and strategically aligned. This is an opportunity to combine scientific depth with visible cross-functional leadership in an entrepreneurial, collaborative and fast-moving environment.

Key Responsibilities

The Clinical Development Lead is the clinical and scientific expert responsible for leading the delivery of clinical program objectives for an assigned compound, in line with Company strategy and agreed development plans.

Main responsibilities include:

• Lead the multidisciplinary Clinical Team at development-program level, providing scientific direction, strategic alignment and accountability across the program.
• Shape innovative clinical development strategies that maximize the compound's value throughout its lifecycle, integrating emerging scientific evidence and evolving standard of care into development plans.
• Lead the scientific development and delivery of clinical sections of trial- and program-level regulatory documents, including Investigator’s Brochures, briefing books, safety updates, submission dossiers and responses to Health Authorities.
• Provide thought leadership in clinical trial design and execution in close partnership with key functions, ensuring scientific quality, clear prioritisation and timely delivery.
• Provide ongoing clinical and scientific review, interpretation and communication of clinical trial data to inform program strategy and development decisions.
• Serve as a core member of the Safety Management Team and contribute to the assessment and communication of the compound’s benefit-risk profile.
• Support the preparation of safety-related documents, including Periodic Safety Update Reports, Drug Safety Update Reports and other safety documentation, in collaboration with the Project Physician and Drug Safety Physician.
• Maintain a strong understanding of the therapeutic area, competitive landscape, relevant mechanisms of action and evolving standards of care.
• Lead clinical contributions to scientific communications, including study abstracts, posters, oral presentations and manuscripts.
• Represent the Company as a credible scientific leader externally with investigators, scientific experts, advisory boards and Health Authorities.
• Champion the clinical perspective in cross-functional discussions and support the continuous evolution of the clinical development strategy.

Candidate Requirements

• Adva…