Research Associate in vitro​/ex vivo models in non-malignant hematology

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In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

pRED Cardiovascular & Metabolism, Immunology and Infectious Diseases (CMI2), located in Basel, Switzerland, focuses on the discovery and early development of innovative treatments for specific diseases that affect the lives of millions. In the cardiovascular and metabolism area, we are developing cutting-edge therapies to treat metabolic diseases.

We're currently looking for a diligent and highly motivated Research Associate to join our non-malignant hematology group. As part of a larger team, you will design and execute in vitro and ex vivo experiments to evaluate the efficacy, safety and mode of action of novel therapies for bleeding disorders such as hemophilia and Von Willebrand Disease.

These responsibilities capture a portion of what your work will look like:

• Validate and apply novel in vitro systems (incl. microphysiological systems, organoids, "organ-on-a-chip") for the assessment of new targets or therapeutic agents that can be leveraged to address bleeding disorders

• Apply state-of-the-art imaging technologies (e.g. confocal imaging) to the analysis of in vitro test systems utilizing patient plasma and blood

• Collaboratively design, execute, and interpret data from in vitro and ex vivo experiments, to assess the efficacy, safety and mode of action of novel therapies in the area of bleeding disorders

• Concisely present experimental data to the group during regular team meetings

• Continuously improve test systems, treatment, analysis, and data evaluation. Contribute to work process optimization including data capture, storage and assay automation

• Work closely with all members of the group, share duties, maintain a clean work environment and actively contribute to the positive work atmosphere within the group

You’re someone who wants to influence your own development. You enjoy teamwork, diligence and efficiency. You are looking for a company where you receive the opportunity to pursue your interests across functions and geographies. Working in a multi-cultural environment motivates you. As a fast learner you actively drive the quality of the requirements.

• MSc/BSc in Life Sciences (cellular/ molecular biology, pharmacology, immunology), or completion of an apprenticeship for a research associate ("Lehrabschluss") with at least 3 years of relevant academic or industry experience

• Experience in confocal microscopy, live cell imaging, and microfluidic systems

• Technical and theoretical background/expertise in in vitro/ex vivo models of hemostasis and thrombosis (including thrombin generation and fibrinolysis assays)

• You communicate effectively in English, both in writing and orally. Skillfully able to interact with people and have strong commitment to teamwork.

• Excellent data management and record-keeping skills

Experience with animal surgery, Experience in applying in vitro analytical technologies such as ELISAs and biochemical assays for data analysis and result evaluation, and prior industry experience are assets for this role

At Roche, we aim high to deliver life-changing healthcare solutions. If you’re ready to make a meaningful impact on patients and healthcare systems…