Principal Site Reliability Engineer

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A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.

Advances in AI, data and computational sciences are transforming drug discovery and development. Roche’s Research and Early Development organizations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The Computational Sciences Center of Excellence (CS CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and life-changing medicines for patients worldwide.

Within the CS CoE organisation, the Data and Digital Catalyst (DDC) organization leads the modernization of our computational and data ecosystems by integrating digital technologies across Research and Early Development to empower stakeholders, advance data-driven science and accelerate decision-making.

The Technical Services and Operations (TSO) group within DDC is accountable for providing application support (Level 1-3) for hundreds of software solutions. In addition, TSO is responsible for Dev Ops and Operations for the DDC’ application landscape, both Cloud and On Premise. Finally, TSO provides technical support for systems that offer tools to train large language models (LLMs) and create autonomous agents, as well as ensuring users are effectively enabled to leverage these advanced systems, from LLM training platforms to autonomous agent building tools.

As a Principal Software Engineer, you will join the TSO Leadership team and will work closely with DDC colleagues as well as directly with our key stakeholders including Computational Scientists, ML Scientists and Research Scientists. You will also work closely with vendors who provide managed services which form the core of many of the TSO activities.

You are an experienced and hands-on technical expert with the proven ability to lead and deliver enterprise scale technical operations. You will be managing operations for Applications and Software and also contributing as an SRE supporting our Infrastructure. Together with the Technical Operations leadership team, you will integrate expertise across on-premises operations, cloud services, and advanced AI/ML technologies. Your strategic focus will be on ensuring high performance, user enablement, and efficient service delivery while effectively managing relationships with external vendors.

This comprehensive approach will drive operational excellence and support the evolving technical needs of our organization.

• Strategic Planning & Service Integration – Develop and implement strategic plans aligned with organizational goals, integrating managed services, on-premises operations, and cloud initiatives while leveraging AI as a key accelerator.

• Vendor & Stakeholder engagement – Vendor relationships, negotiate contracts, and ensure adherence to SLAs.

• Operational Excellence & Change Management – Applying software engineering principles to operations to scale and maintain highly reliable production systems, balancing the rapid release of new features with uncompromising system stability and performance. Establish Service level metrics (SLA, SLO, SLI), error…