RiSM Internship: Spray-Drying & Solid-State Development

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Pharmaceutical & Solid State Development is part of Pharma Technical Development and situated in Basel, Switzerland.

Our key expertise is the development of robust and economic processes for drug substances with tailor‑made solid state properties and patient centric formulations for the synthetic molecule portfolio of projects from early clinical studies to commercialization. We advance the design and delivery of transformative medicines by combining particle engineering, characterization, and formulation development - ensuring optimal drug performance, manufacturability, and patient-

centric solutions from molecule to medicine.

As an intern you will support the Pharmaceutical & Solid State Development isdepartment the impact of spray drying conditions on downstream processing and drug release of amorphous solid dispersions.

• Review of the relevant literature applicable to the project

• Training in relevant SOPs and manufacturing/analytical equipment

• Planning, execution and evaluation of laboratory experiments

• Manufacturing and characterization of spray dried powders

• Regular discussion of project progress with supervisors and planning of next steps

• Writing of final report

You are a University student (or you graduated within 12 months prior to the start date)
preferably in the subject of Chemical Engineering, Pharmaceutical Sciences, Pharmaceutical Technology or related subjects and have an interest in technical aspects. Furthermore, you are interested in using and sharing your knowledge as part of your Internship in a modern working environment. Your further profile for this position:

• Reliable and accurate working style in a non-GMP environment

• Team-oriented and decision‑making personality

• Self‑sufficient, problem solving-oriented work habits

• Good knowledge of MS-Office (Word, Excel, PowerPoint)

• Proficiency in English, German is a plus

This internship opportunity is one of a number of positions we offer in the department per semester and is not suitable for writing a Bachelor/Master/Diploma thesis.

The interviews will take place on an interview day with all considered candidates and representatives of the department.

Your complete application includes the following documents:

• A Current CV and a Motivation Letter

• A certificate of enrollment (if you are currently studying)

• For Non-EU/EFTA citizens:
  Due to regulations, you must provide a certificate issued by your university stating that an Internship is mandatory for your studies and you must be enrolled during the entire duration of the internship

• The RiSM task (see below)

The Final date to receive applications is 23.08.2026. All successful final candidates will be invited to a virtual interview day which will take place on 14.10.2026.

The Internship will start in January to March 2027 and has a duration of 9 to 12 months, please indicate your preferred start date in your application.

More information about the Roche Internship program in Synthetic Molecules (RiSM) and other opportunities within this program you can find here.

Assume you are a formulation scientist that has the task to develop a poorly water soluble drug (MW 923.43 g/mol, LogP≈ 5.5 - 7.5. Solubility DMSO: up to 100 mg/mL, Ethanol: up to ≈ 3-6

mg/mL) for the treatment of head-neck-cancer.

What are your considerations with respect to the formulation, manufacturing technology and dosage form?

Please use the information provided in the following article (Dana

E. Moseson, Trong Bien Tran, Bharathi Karunakaran, Rohan Ambardekar, Tze Ning Hiew, Trends in amorphous solid dispersion drug…