Principal Scientist, Mid​/Scale Oligonucleotide Synthesis, xRNA Therapeutics

Job Description Summary

Location:

Basel, Switzerland #onsite

Role

Purpose:

We are seeking a highly motivated and experienced PhD-level scientist to lead our mid/large xRNA synthesis team in Basel. This position requires extensive collaboration within a multidisciplinary environment, bridging research and development to discover and advance innovative siRNA therapies addressing significant unmet medical needs.

• Oversee a state-of-the-art oligonucleotide synthesis facility, managing both capital and consumables budgets efficiently.
• Lead and guide a team of scientists specializing in oligonucleotide synthesis and purification of oligonucleotides at millimole scale to deliver on our growing siRNA portfolio.
• Ensure the delivery of high-quality siRNA products for both in vitro screening and in vivo evaluation within drug candidate pipelines.
• Collaborate with discovery xRNA existing oligonucleotide synthesis teams in Basel as well as in Cambridge.
• Provide technical leadership to the scale-up team in the synthesis of oligonucleotides, optimize methodologies and processes to improve efficiencies.
• Collaborate with synthetic chemists and project teams to scale up new siRNA chemistries that address critical scientific challenges and facilitate their seamless transition into development.
• Document and effectively communicate results and scientific insights to internal and external stakeholders through patent applications and scientific publications.
• Mentor and support team members by sharing technical expertise and hands-on experience within the work environment.
• Excellent problem solving skills and solution-oriented mindset.

• A PhD in synthetic chemistry focused on oligonucleotides. 2–3 years experience in the industry setting.
• Proven practical experience in oligonucleotide solid-phase synthesis and downstream processing with expertise in a mid/large scale oligo synthesis and in process development.
• Demonstrated leadership abilities and experience developing scientific teams.
• Capacity to promote and implement innovative ideas within a global team context.
• Strong independent problem‑solving skills.
• Proven collaborative attitude.
• Proficiency in managing multiple priorities effectively while maintaining focus where necessary.
• Excellent verbal and written communication abilities.

Novartis is committed to building an outstanding, inclusive work environment and diverse teams that represent the patients and communities we serve.

Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e‑mail to inclu and let us know the nature of your request and your contact information.

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