Analytical Molecular Characterization Team Lead and Mass Spectrometry Scientist

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life‑changing innovation at speed.

This position is located in Preclinical Chemistry, Manufacturing, and Control (pCMC), a department within the Synthetic Molecule Research organization in pRED Therapeutic Modalities, where we pave a diverse, ambitious and innovative environment, the path to bring drug candidates from early research into development. We are CMC experts and build our strength on a broad diversity of technical expertise in chemistry, formulation design, material science and analytical chemistry, delivering and innovating in the space of small molecules, peptides and nucleic acid based medicines.

We offer an exciting opportunity for an experienced CMC professional to lead our Analytical Molecular Characterization (AMC) team while serving as a hands‑on Mass Spectrometry (MS) subject matter expert. In this role, you will bridge discovery research and technical development, driving advanced analytical strategies to support our portfolio across the value chain.

You will lead a multidisciplinary team spanning NMR, MS, and chromatography, while developing and applying high‑resolution MS methods for the characterization of synthetic molecules. This role combines strategic leadership with hands‑on scientific contribution, shaping both team direction and analytical excellence.

• Lead and develop a team of analytical experts across MS, NMR, and chromatography
• Define and execute mid‑to‑long‑term AMC strategies aligned with project and portfolio goals
• Foster collaboration across discovery, technical development, and external partners

• Develop and apply advanced high‑resolution MS methods for structure elucidation and impurity characterization
• Oversee complex analytical activities, including stereo chemistry determination and interaction studies (API‑excipient)
• Drive analytical method development across SFC, HPLC, and GC for small molecules and peptides

• Partner with Data, Digital, and AI teams to advance data workflows, automation, and analytics capabilities
• Identify industry trends and maintain academic collaborations to ensure scientific leadership
• Ensure high‑quality analytical support for IPCs, intermediates, and APIs across development stages

• PhD in Analytical Chemistry (or related field) with 5+ years industry experience, or MSc with 10+ years
• Strong expertise in chromatographic and spectroscopic techniques, with deep MS experience in structure elucidation
• Knowledge of API synthesis, impurity profiling, and separation technologies (U/HPLC, SFC)
• Proven leadership experience (≥3 years) managing multidisciplinary teams
  
  Familiarity with GMP and regulatory requirements
• Strong collaborator able to connect technical depth with strategic objectives