Discovery Scientists, in vitro and in vivo Pharmacology, in Cardiovascular & Metabolic Disease

The Position

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients. pRED Cardiovascular & Metabolism, Immunology (CMI) in Basel, Switzerland focuses on discovery and early development of treatments for metabolic diseases. We are hiring four experienced PhD-level Discovery Scientists to join our Cardiovascular & Metabolic Disease Research team. These opportunities include two in vivo-focused and two in vitro-focused positions
. Candidates should have strong expertise in in vitro and/or in vivo pharmacology, a solid industry background, and a proven track record in executing preclinical projects in metabolic diseases and immunology.

In this role, you will design and execute experiments and lead projects to evaluate the efficacy and safety of novel therapeutic candidates.

• Lead research projects in metabolic diseases (insulin resistance, obesity) from target ideation to entry into clinical development for both small- and large-molecule modalities.
• Drive the positioning and prioritization of novel metabolic and immunological targets, integrating disease biology, translational biomarkers, and therapeutic modality selection to align with Roche’s CVM pipeline.
• Collaboratively design, execute, and interpret complex preclinical in vitro and in vivo experimental studies for the validation and characterization of targets or therapeutic agents.
• Direct, execute, and benchmark novel experiments, work together with associates, and transfer standardized assays to associates.
• Act as a resource in project teams and demonstrate clear and professional verbal and written communication.

• You possess a PhD degree in Life Sciences; specialized in metabolic diseases (insulin resistance, obesity, muscle-/adipose-physiology).
• You have >5 years of research and project leadership experience in the pharmaceutical industry.
• You have demonstrated ability to effectively present scientific data and concepts to colleagues, teams, and management.
• Skillfully able to interact effectively with people, both internally and externally.
• Vigorous “can do” mentality to succeed in a dynamic and highly collaborative research team.
• Depending on your background, this role is embedded in an in vivo–focused or in vitro-focused research team.

Roche is an Equal Opportunity Employer.