Post Doctorate Scientist – Vascularized Kidney Organoids - Institute of Human Biology; IHB

Position:
Institute of Human Biology (IHB), Roche’s Pharma Research and Early Development (pRED) Division. IHB is a leading research institute focused on accelerating the development of transformative medicines by developing novel and robust human model systems.

We are building next‑generation human kidney models by tackling a central unsolved problem in the field: how to generate organotypic, vascularised kidney organoids that show enhanced maturation.

As part of a newly funded IHB fellowship, you will drive an ambitious research programme at the interface of stem‑cell biology, vascular biology, and single‑cell genomics with the goal of creating translationally relevant systems for drug discovery and safety.

• Drive the development of vascularised iPSC‑derived kidney organoids, with a focus on tissue specification and maturation.
• Use single‑cell genomics to dissect endothelial specification, nephron maturation and cell‑cell communication.
• Work closely with bioengineers to integrate biology into perfusable, next‑generation culture systems.
• Translate biological insights into functional, predictive models relevant for human kidney safety.

• Scientist with a PhD and a strong track record in iPSC‑derived 3D tissue models or organoids.
• Completed doctoral studies within the last four years.
• Experienced in generating and analysing single‑cell transcriptomic data and comfortable translating complex datasets into biological insight.
• Scientifically ambitious, with the ability to drive new concepts rather than follow established protocols.
• Ideally, strong background in developmental biology, with expertise in kidney, vascular or related organ systems.

You will be embedded in a highly interdisciplinary ecosystem at IHB, working with leading experts in bioengineering, stem‑cell biology and computational analysis, and closely connected to Roche’s drug discovery and safety teams. This is a unique opportunity to define how human kidney models are built and used in the future—from fundamental biology to direct impact on drug development.

Roche is an Equal Opportunity Employer. We believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives. We are courageous in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all.

We do this today to build a better tomorrow. We are proud of who we are, what we do, and how we do it. We are many, working as one across functions, across companies, and across the world. We are Roche.