Technician CLD

The Position

The Technician CLD supports the development of processes and/or the analysis for the manufacturing of recombinant proteins with CHO cultures by executing experiments, preparing materials, and collecting data.

• Conduct experiments and apply standard laboratory practices under moderate guidance and supervision within scope and timelines
• Document executed work in accordance to internal guidelines
• Support troubleshooting activities in collaboration with Subject Matter Expert
• Document batch results with a critical mind
• Write protocols, SOPs, using available templates
• Drive simple initiatives (in relation to job duties) with limited guidance and supervision within your team/group
• Support technology transfer activities if needed
• Follow all EHS procedures and laboratory safety standards, maintain a clean and safe workspace, and promptly report any unsafe conditions, incidents, or near misses

Cell Line Development (CLD) technical skills:

• Gene synthesis, vector cloning, plasmid purification, sequencing, agarose gel electrophoresis
• Plasmid design software (e.g., vector mapping and annotation tools)
• Transfection techniques and clone selection workflows;
  Clonality assessment (e.g., FACSAria, FACSLyric, Single cell printing (VIPS), Cellmetric)
• Expansion and cryopreservation of cell lines
• Small-scale bioreactor systems used in early screening (e.g., Ambr
  15, Breez)
• E.coli culture, CHO cell suspension culture

Other desirable technical skills:

• Cell culture expansion in shake flasks, wave bags, and benchtop bioreactors
• Use of single-use bioreactors at laboratory and pilot scale
• Monitoring and control of critical culture parameters (e.g., pH, DO, temperature, agitation, feeding)
• Routine sampling for cell growth and metabolic profiling
• Basic troubleshooting and maintenance of bioreactor and support systems

• Excellent communication skills (English required, German is a plus)
• Solution-oriented mindset
• Ability to work in a fast-paced environment
• Collaborative team player
• Ability to deal with changes and quickly adjust to new situations

• Make a difference by directly impacting patients lives
• Biologics is an attractive, high growth sector with professional development
• Offers a multinational and diverse workplace
• Proud to be a pioneer in “Next Generation” manufacturing technologies
• Family owned:
  Entrepreneurial, and short communication lines
• Basel is a great place to live, play and work in the center of Europe