Hematology and Safety Biomarker Expert

Position Overview

This position is located in Pathology and Applied Safety Science, a department within the Pharmaceutical Sciences function  role focuses on the non‑clinical safety assessment of drug candidates from discovery to development.

• Strategically integrate and execute integrated in‑vitro and in‑vivo hematology and safety biomarker strategies; provide subject‑matter expertise for clinical candidate selection and deliver comprehensive safety risk assessments for regulatory documentation (e.g., IND/CTA).
• Allocate approximately 50% of working time to wet‑lab work, developing and implementing tailored in‑vitro and ex‑vivo hematology and fluid‑based safety biomarker assays, and generating and compiling clinical pathology data (hematology, coagulation, clinical chemistry, urinalysis).
• Partner with Digital Pathology and modelling experts to develop screening assays, utilize digital and data‑curation platforms (e.g., LIMS, SLIMS, Arvados) for streamlined data transfer and harmonized datasets, and optimize workflow integration.
• Manage external partnerships and coordinate outsourcing of relevant assays to CROs, ensuring strict adherence to timelines and data quality standards.
• Maintain strict compliance with Safety, Health, and Environmental regulations, fostering a culture of safe laboratory practices.
• Demonstrate highly collaborative skills across agile, cross‑functional project teams, supervise and train technical staff, apprentices, postdocs, or students.
• Continuously optimize laboratory processes to improve quality, efficiency, and sample‑handover timelines.
• Establish networks with Key Opinion Leaders and participate in cross‑industry working groups (e.g., FNIH Biomarkers Consortium, PSTC) to track scientific and regulatory trends.

• Hold a DVM with a PhD or relevant specialization; a PhD in Hematology, Biology, Immunology, or Toxicology; or a Master’s degree combined with significant practical experience in in‑vivo toxicology.
• Demonstrated hands‑on experience in wet‑lab environments, specifically with in‑vitro and ex‑vivo safety biomarker assays or clinical pathology data generation.
• Familiarity with digital data platforms, data‑curation tools, or automated workflow integrations.
• Strong communication and relationship‑building skills, with an outstanding ability to collaborate effectively across multidisciplinary, global teams.
• Continuous improvement mindset dedicated to optimizing laboratory processes and mentoring emerging scientific talent.

Roche is an Equal Opportunity Employer.