Sr. Scientist - Computational Biology - Neuroscience & Rare Diseases

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The Computational Sciences Centre of Excellence is a global organisation enabling Roche’s Research and Early Development units to develop novel therapeutics that will have an impact on patient lives. Within the Computational Sciences Centre of Excellence, the Computational Biology and Medicine department focuses on furthering our understanding of disease pathogenesis, patient populations, and target biology by having access to the largest Pharma R&D datasets in the world.

In partnership with our scientists across Roche, we create better medicines by augmenting every part of R&D through our data-driven culture.

We are seeking a highly motivated computational scientist to join our Neuroscience and Rare Diseases therapeutic area. In this role, you will be a key member of an interdisciplinary team dedicated to advancing our understanding of neurological diseases. As Roche continues to build and advance its capabilities in computational and data-driven R&D, this position offers an integral role in our strategy.

You will identify novel therapeutic targets and biomarkers by analyzing high-dimensional data. You will collaborate closely with leading laboratory scientists and clinicians, contributing directly to a pipeline of innovative medicines for patients with neurodegenerative and neuroinflammation diseases. You will also be part of the wider Computational Biology and Medicine unit of the Computational Sciences Centre of Excellence drawing on the shared experience and expertise of colleagues globally.

• Lead the analysis of high-dimensional datasets such as single-cell, spatial, proteomics, metabolomics, and human genetics data to support therapeutic and biomarker development
• Collaborate closely with the AI/ML Foundation Model development teams and apply advanced quantitative methods, supporting drug discovery projects in Neuroscience and Rare Diseases.
• Deliver clear and objective data-driven insights to inform portfolio decision-making

• Contribute to the data and analytics strategy for Neuroscience and Rare Diseases efforts in collaboration with partners in the therapeutic area
• Develop effective working relationships with key stakeholders in the disease therapeutic area, laboratory teams, and computational teams

• Contribute to a collaborative workplace culture of scientific rigor, continuous improvement, and open feedback
• Support the scientific growth of team members by sharing knowledge and expertise

You are a dedicated scientist with a strong background in applying computational methods to biological problems. You are motivated by scientific challenges and have a clear interest in translating data into meaningful biological insights.

• PhD in Bioinformatics, Biostatistics, Computational Biology, or a similar field with 3-5 years relevant work…