Subject Matter Expert Oral Enabling Formulation Technologies

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In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

Therapeutic Modalities (TMo) organization, accountable for translating disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines. By integrating deep modality expertise with cross-disciplinary collaboration, TMo drives innovation within and across platforms to enable differentiated, sustainable therapeutic impact.

We are CMC experts and build our strength on a broad diversity of technical expertise in chemistry, formulation design, material science, and analytical chemistry, delivering and innovating in the space of small molecules, peptides, and nucleic acid based medicines.

As Subject Matter Expert (SME) in Oral Enabling Formulation Technologies. This is a high-impact, technical leadership role focused on overcoming the challenges of poorly soluble or poorly permeable drug candidates. You will lead the strategy, design, and execution of advanced formulation platforms to drive our pipeline from discovery through clinical proof-of-concept.

Enabling Formulation Mastery:

• Establish a high-impact technical network to maintain state-of-the-art oral enabling formulation technologies for delivery of complex synthetic modalities.
• Design and execute specialized formulations (e.g., lipid based-delivery systems such as SMEDDS/SNEDDS, amorphous solid dispersion spray-dried, hot-melt extrusion) to maximize exposure in PK, PD, and safety studies.
• Drive the advancement of global formulation strategies by integrating novel delivery technologies to enhance absorption and therapeutic efficacy.
• Lead the technical profiling of NCEs and conduct rigorous Develop ability Assessments to identify and mitigate risks in molecular properties early in the pipeline.

Internal Advisory

Collaboration:

• You act as subject matter expert (SME) for internal pRED scientists, advising on formulation strategies for complex synthetic molecules and fostering collaborative innovation across the organization.

Portfolio Execution & Excellence:

• Act as pCMC Drug Product lead within research project teams, guiding the end to end CMC scientific strategy until transfer to the Technical Development Department.
• Plan, coordinate and effectively communicate with research teams, function, stakeholders and governance boards.
• Master Modeling & Simulation and AI/ML tools to predict drug performance, optimize formulation selection, and bridge in vitro data to in vivo outcomes.
• Ensure scientific excellence and operational efficiency while meeting dynamic portfolio needs through effective internal and external supply strategies.

You possess a very strong background in Pharmaceutical Research and Development, Chemistry or related field. Ideally you have obtained a PhD in Pharmaceutical Technology and have at least 8 years of industry experience in Drug Discovery/Development, with at least 3-5 years specifically focused on Enabling Formulation Technologies for Oral Drug Delivery.

• A strong knowledge and experience in Enabling Formulation Technologies like Lipid Based Formulations and Polymer Stabilized Amorphous Systems from Screening to Proof of Concept and…