Technical Development Scientist

Chez Roche, vous pouvez être vous-même et être apprécié pour les qualités uniques que vous apportez. Notre culture encourage l'expression personnelle, le dialogue ouvert et les connexions authentiques, où vous êtes valorisé, accepté et respecté pour ce que vous êtes, vous permettant de prospérer tant personnellement que professionnellement. Voici comment nous visons à prévenir, arrêter et guérir les maladies et à garantir à chacun l'accès aux soins de santé aujourd'hui et pour les générations à venir.

Rejoignez Roche, où chaque voix compte.

Roche is seeking a highly motivated and passionate Senior or Principal Scientist to join the crystallization and solid state development teams at Roche in Basel, Switzerland. The successful candidate will work in the Particle Design section within the small molecule organization and develop and scale up novel crystallization and precipitation processes in close collaboration with chemistry and formulation colleagues in development and production.

The ideal candidate will have a strong background in crystallization, filtration and drying, and have the ability to apply chemistry and chemical engineering principles to solve challenging problems. Additionally, the candidate should have a strong affinity for digitalization to drive innovation and efficiency in process development.

As part of the crystallization team, you will work in a highly dynamic and cross-functional environment within the PTDC-P organization. You will be responsible for developing chemical processes that achieve the necessary purity, crystal form (polymorph) and particle properties. The successful candidate is additionally expected to drive research efforts and implement new technologies that solve key CMC problems.

The position is located at the interface between synthetic and analytical chemistry and formulation and requires close collaboration with functional stakeholders. The candidate should exhibit excellent interpersonal skills for effective collaboration with interdisciplinary teams and demonstrate a solid understanding of end-to-end process development for small molecules. Frequent presentations and team interactions are expected. The candidate will also be responsible for authoring filing documents to regulatory authorities.

• Design, optimize, and scale phase-appropriate crystallization, precipitation, and isolation processes under non-GMP and cGMP conditions to achieve target purity, crystal forms (polymorphs), and physical particle attributes.

• Define commercial manufacturing design spaces and operating ranges, ensuring robust control over drug substance quality attributes through a mechanistic understanding of underlying physical chemistry principles.

• Serve as a key technical interface within the Particle Design section (PTDC-P) in Basel, bridging synthetic chemistry, analytical development, production, and formulation to resolve complex solid-state pipeline challenges.

• Drive innovation and digital transformation by applying advanced process development tools, molecular or process modeling, and new solid-state methodologies to optimize particle properties.

• Author and review comprehensive technical reports, cGMP manufacturing instructions, process validation documentation, and key technical sections for regulatory filing submissions.

• Lead internal and external matrix collaborations, coordinating with cross-functional project teams, vendors, and academic partners to solve complex CMC (Chemistry, Manufacturing, and Controls) challenges.

• Expand unit operation strategies by leveraging techniques such as wet/dry milling, spray drying, or co-processing, especially for challenging small molecules, peptides, or semicrystalline materials.

• Actively contribute to and advance the internal and external scientific community by sharing technical expertise, presenting research findings, and implementing cutting-edge technologies.

• Ph.D. in Chemical Engineering, Physical Chemistry, Materials Science, Pharmaceutical Science, or a related field with 0-5 years of pharmaceutical industry experience (or an M.Sc. with 7-15+ years of relevant industry experience).

• Proven…