Senior) Research Associate​/Senior) Scientist, throughput Proteomics in Targeted Protein Degradation

We are looking for several highly motivated (Sr) Research Associates/ (Senior) Scientists responsible to support one of Ridgeline Discovery’s portfolio company about to come out of stealth mode.

The successful candidate will have experience in High throughput screening and/or Mass Spectrometry-Based Drug Discovery ideally applied to targeted protein degradation (job title will be based on previous experience). She/he will be a highly motivated and enthusiastic team player with proven organizational skills, and a strong scientific background to impact early and late-stage development projects.

• Collaborate with cell biologists to prepare samples for MS-based screening, operate state-of-the-art high resolution mass spectrometers, analyze and interpret multi-layered data, and present findings to stakeholders and external collaborators.
• Develop and implement sample preparation and automation protocols, optimize mass spectrometer performance, and adapt novel technologies.
• Oversee data generation and analysis of large-scale proteomics datasets.
• Work closely with an interdisciplinary team to identify potential novel drug targets.
• Stay engaged with scientific literature to remain up-to-date with the latest developments and novel approaches.
• Be proactive and open-minded in contributing to the achievement of the company’s goals in a dynamic and fast-paced start-up environment.
• Characterize novel drug targets and their mechanisms of action.
• Contribute to laboratory general organization and maintenance, manage laboratory stocks and ordering.
• Ensure compliance with good laboratory practices including safety regulations, data management, data recording in electronic notebooks and archiving.

• Research associate level: you hold a Master, Bachelor degree or laboratory apprenticeship (or equivalent) in Biotechnology, Biochemistry, Molecular Biology, with at least 2 years of experience in academia, contract research, or the biotechnology/pharmaceutical industry, particularly in the field of proteomics.
• Scientist level: you hold a PhD in Biochemistry, Biology, Chemical Biology or other relevant disciplines and preferentially 2+ years’ relevant MS experience in drug discovery in the pharmaceutical, biotech or MS contract research setting.
• You are skilled in designing, planning, and executing laboratory experiments and are passionate about analyzing data and sharing your findings.
• Experience with the latest generation UHPLC systems and mass spectrometers (such as Orbitrap Astral or timsTOF) for in-depth proteome characterization and/or targeted analysis is a plus.
• Experience in high-throughput peptide/protein sample preparation (S-trap/SP3/PAC), automation (Tecan/Biomek/Hamilton/Agilent Bravo/OT-2) and DIA (data-independent acquisition) data analysis is desired.
• Knowledge of Spectronaut or DIA-NN and bioinformatics tools, such as R or Python, is a plus.
• You are an organized team player, adept at critical thinking and problem solving, with excellent communication skills in English.
• Must be highly independent, able to work well in a highly collaborative team-oriented environment. Capable of thriving and multi-tasking in a fast-paced “start-up” environment.
• Self-motivated, willingness to learn, strong work ethic, attention to detail, organizational skills, and excellent communication skills are required for this position.
• Fluency in English required

Closing date: 30th of September

• Prime
  
  Location:
  
  Our state-of-the-art laboratories and modern offices are located at the Technologiepark Basel, one of the city’s leading hubs for innovative and ambitious life-science start-ups.
• Commuter Benefits:
  We support your individual commuting needs with flexible options, including parking…