Scientist – Oligonucleotide Chemistry & Innovation

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In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

Therapeutic Modality (TMo) organization, accountable for translating disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines. By integrating deep modality expertise with cross-disciplinary collaboration, TMo drives innovation within and across platforms to enable differentiated, sustainable therapeutic impact.

As an experienced Scientist in Oligonucleotide Chemistry, you will serve as a key architect behind our therapeutic pipeline, translating advanced chemical concepts into optimized lead candidates. In this strategic role, you will champion the rational design and chemical modification framework for next-generation small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs). Collaborating seamlessly with our computational platforms and discovery teams, you will guide the creation of proprietary libraries and establish structure-activity relationships to accelerate candidate selection.

By synthesizing cutting-edge literature, emerging technologies, and external innovations, you will continuously elevate our core chemical design strategies and position our platform at the forefront of genetic medicine.

• Design and champion the rational chemical modification framework for next-generation oligonucleotides—including siRNAs and ASOs—to advance critical drug discovery projects.
• Collaborate seamlessly with computational experts and synthesis teams to create high-value, novel oligonucleotide libraries, bridging theoretical chemistry with data-driven design.
• Analyze experimental data using advanced computational methods, applying continuous learning cycles to systematically refine and elevate chemical designs.
• Translate innovative chemical concepts into synthetically accessible structures with precision and attention to detail.
• Stay at the forefront of emerging technologies and external breakthroughs to identify novel ways to improve safety profiles, durability, and therapeutic performance.
• Partner across multidisciplinary teams—including biology, pharmacology, and toxicology—to evaluate biological impacts and guide strategic decisions in a highly collaborative environment.

• You hold a Ph.D. in Oligonucleotide Chemistry, Organic Chemistry, or a related discipline, complemented by 3 to 5 years of industry experience in the biotech or pharmaceutical sectors. Experience across different oligonucleotide modalities is highly desirable.
• You bring deep expertise in translating chemical modifications of oligonucleotides into innovative drug candidate designs.
• You possess a comprehensive understanding of modern oligonucleotide modification patterns (such as 2'-O-methyl, 2'-fluoro, LNA, cEt)…