Associate Director, Commercial Supply Chain Management & Planning Bedford, Massachusetts

Bedford, Massachusetts, United States

About Stoke:

Stoke Therapeutics(Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study.

Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit

Position Summary

The Stoke Therapeutics team is seeking an experienced and driven Associate Director, Commercial Supply Chain Management and Planning to lead the planning, forecasting, and execution of commercial supply strategies that ensure uninterrupted drug availability. This individual partners cross-functionally with Commercial Operations, Quality, Regulatory, Manufacturing, and external vendors to drive demand and supply planning, launch supply plans, and cold-chain logistics to help build and scale the function.

The role plays a critical part in leading commercial supply chain activities from launch through steady-state operations, including artwork development, CMO timeline management, and DSCSA / Serialization compliance, while also supporting demand planning and ERP setup and design.

The ideal candidate possesses strong expertise in commercial supply management, forecasting, inventory planning, ERP systems, and cross-functional collaboration, with excellent communication, organizational, and problem-solving skills.

Key Responsibilities:

• Lead the execution of the commercial supply chain strategy, helping build capability from initial launch into a scalable operating model.
• Lead supply chain coordination of commercial artwork management and secondary packaging workstream.
• Own day – to – day demand and supply planning activities and support the implementation and facilitation of the S&OP process.
• Ensure compliance with GxP, DSCSA/serialization, and applicable global regulatory requirements across the distribution network.
• Develop launch supply plans in collaboration with CMC, QA, RA, and Commercial Operations.
• Drive supply planning for both clinical and commercial supply chains.
• Support the execution of cold-chain logistics, including temperature integrity and chain of custody.
• Partner with Quality to support GxP compliance, including change controls, continuous improvement, and deviation handling.
• Track and manage timelines for internal activities and external CMO production activities to support continuous supply of commercial materials.
• Support development of Commercial Supply Chain SOPs for inspection readiness and GxP compliance.
• Serve as a supply chain representative in ERP setup, configuration, and design decisions.

Required

Skills & Experience:

• Bachelors in Life Sciences required.
• Minimum 8-10 years in Commercial Supply Management or a related field.
• Proficient knowledge of Microsoft Excel, PowerPoint and Project software required.
• Strong foundation in S&OP, demand and supply planning, inventory management, and distribution network strategy.
• Understanding of pharmaceutical distribution models, specialty distribution/pharmacy, 3PLs, and…