Senior​/Staff Scientist, Surface Chemistry Berkeley, CA

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

We are seeking a highly skilled and experienced Surface Chemist who will be responsible for developing solid-phase supports for DNA synthesis and protein sequencing via Glyphic’s proprietary technology. This role reports to the Director of Chemistry and requires expertise in surface chemistry, solid-phase synthesis, and analytical techniques. The successful candidate will work independently in a laboratory environment and collaborate effectively with cross-functional teams.

This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

• Develop solid supports that meet the physicochemical performance requirements for a novel single molecule protein sequencing workflow and will be compatible with automation equipment.
• Source and synthesize custom supports to investigate surface functionalization, porosity, size, stability, and manufacturability.
• Optimize functionalization chemistries (includes covalent, cleavable, linkers, passivation) to improve interfacial reaction kinetics and efficiency and assay signal-to-noise.
• Develop and validate analytical methods to characterize/QC solid supports.
• Develop and validate functional testing methods to characterize/QC solid supports.
• Partner with scientists and engineers to deploy novel supports into SOP workflows.
• Design and execute experiments bridging chemistry and molecular biology.
• Analyze experimental data, generate detailed reports, and provide actionable insights to guide further development.
• Apply statistical methods and process evaluation tools to ensure workflow quality and performance.
• Prepare and maintain comprehensive documentation of protocols, SOPs, and results.
• Contribute to process innovation and support technology transfer as workflows mature.

• Degree in organic chemistry, surface chemistry, bioengineering or equivalent field. Advanced degree preferred.
• 6+ years (PhD), 8+ years (MS), 10+ years (B.S.) of industry or equivalent experience in assay or reagent development.
• Demonstrated proficiency in surface and morphological characterization (AFM, SEM/TEM, XPS, contact angle, DLS, zeta potential).
• Expertise in surface and solid-phase chemistry, including surface modification, functional group coupling (and quantitation), and polymer or nanoparticle surface engineering.
• Demonstrated proficiency in analytical characterization, including LC–MS, HPLC, FTIR, UV–Vis, fluorescence spectroscopy, and elemental analysis.
• Hands‑on experience with bioconjugation chemistry, such as coupling of proteins, peptides, small molecules, or oligonucleotides via covalent or affinity‑based linkers.
• Excellent problem‑solving skills and attention to detail.
• Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds.
• Ability to thrive in a fast‑paced environment with evolving priorities.

• Familiarity with microfluidics and flow cells.
• Experience in photochemistry and photocatalysis.
• Experience with automation platforms for liquid handling (e.g. Hamilton, Thermo Fisher, Agilent).
• Familiarity with statistical methods or computational tools for process/data analysis.
• Experience supporting technology transfer into production environments.

• Excellent interpersonal skills – capable of building strong relationships and communicating effectively with stakeholders at all levels.
• High emotional and analytical intelligence – able to navigate complex team dynamics, partnerships, and challenges with creativity and logic.
• Resourceful adaptability – operates with urgency, remains flexible in evolving environments,…