Principal Scientist - Antibody Discovery

Principal Scientist - Antibody Discovery

Full Time

Antibody Discovery

The heart of Prellis Bio’s strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and next gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications.

To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

We are seeking a highly motivated and experienced Principal Scientist in the field of Antibody Discovery, NGS and Molecular Biology to lead innovative research and development initiatives.

You will play a key role in identifying Prellis’ large molecule therapeutics by supporting various discovery and non-GLP preclinical studies. You will also be responsible to supervise lab staff, recruit staff, and manage outside service partnerships.

You will report to the CSO and work at our headquarters in Berkeley, CA.

Your primary responsibilities will include:

• Antibody discovery:
  Will lead a team of scientists on Prellis’ breakthrough EXIS (lymph node organoid) platform, novel 10X and Single B-cell cloning methods, combined with NGS to discover antibodies for a range of portfolio therapeutic targets.
• Molecular biology:
  
  Will contribute to innovation in molecular biology of antibody cloning, expression, and generation of NGS libraries.
• Data analysis:
  
  Will utilize advanced bioinformatics tools and techniques to analyze large NGS datasets, including V-genes, and B-cell transcriptomic for antibody discovery and development. The ability to use antibody sequence data and associated properties to train predictive and generative ML-models will be considered as a plus.
• Mentorship:
  
  Provide guidance to Ph.D. and non-Ph.D. scientists in immunology, data science, and molecular biology.
• Collaboration:
  
  The ability to multi-task and manage multiple projects, whilst working closely with data scientists, immunologists, protein engineers, and molecular biologists to translate bioinformatics findings into actionable insights for therapeutic development. Lead cross-functional teams to achieve project goals.
• Communication:
  Strong verbal and written communication skills with a high degree of motivation, creativity and collaborative qualities.
  
  Present research findings clearly and effectively to internal stakeholders. Prepare detailed reports and presentations.

You will join a growing and well-positioned a pre-IPO biotech startup that is very much in formation. Anticipate a lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work with a very experienced leadership team, learn a broad range of skills, and help shape Prellis Bio's culture, strategic direction, and outcomes. Join us and help make a difference to patients!

About You

• Education:
  
  Ph.D. in molecular biology, immunology, bioinformatics, or a related field.
• Experience:
  
  Ph.D. in Biochemistry, Molecular Biology, Cell Biology, Immunology, or a related field with 3-4 years of relevant experience within an academic or industrial setting; or Master’s degree and 5 years of relevant experience within an academic or industrial setting; or Bachelor’s degree and 7 years of relevant experience within an academic or industrial setting
• Technical
  
  Skills:
  
  Proficiency in antibody discovery techniques, B-cell biology, and therapeutic development processes.
  
  Experience with bioinformatics tools for antibody sequence analysis, structural modeling, and machine learning applications.
  
  Knowledge in programming languages such as Python or R for data analysis will be a plus.
• Soft Skills:
  
  Strong problem-solving abilities, excellent communication skills, and the capacity to work effectively in a multidisciplinary team.

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug…