Senior Scientist, Assay Research

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you

We are seeking a curious, hands-on scientist for an Assay Research Scientist position. Reporting to the Director of Assay Development, you will establish novel assay workflows, define the requirements for new components such as beads, surface chemistries, and sample prep approaches, and develop proxy assays that predict multi-cycle ProSE performance. You will work at the interface of molecular biology, chemistry, bioinformatics, and automation, partnering closely with the Chemistry and Integration teams.

The ideal candidate can connect assay outcomes to the physical and chemical mechanisms behind them, and translate those insights into clear requirements for new components.

In this role, you will have the unique opportunity to shape how our ProSE platform evolves. Replacing slow, empirical testing with predictive, mechanistically grounded assays that will help us build and improve our protein sequencing technology faster and with greater confidence, and move us toward our mission to revolutionize life science discovery.

This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

What you’ll do

• Design, plan, and execute experiments to improve the efficiency, accuracy, and scalability of Glyphic’s protein sequencing by expansion (ProSE) process.
• Establish novel assay workflows and determine the requirements for novel components needed to support them.
• Develop proxy assays that isolate workflow and component variables, accelerating integrated solutions and predicting multi-cycle performance without a full end-to-end run.
• Propose, design, and test novel analytical approaches to optimize and build predictive understanding of critical components of the ProSE sequencing process including sample preparation, molecular expansion chemistry, automation, and the integration of these components into a robust end-to-end assay.
• Correlate assay findings to the physical characteristics of the system using multimodal characterization, and connect assay outcomes and mechanistic understanding to new component requirements.
• Proactively identify, communicate, and help address experimental risks or resource gaps, such as reagent supply or instrument issues.
• Partner with peers on the Assay Development team to deliver team goals and prioritize experiments accordingly.
• Collaborate with scientists and engineers on the Chemistry, Assay Integration, Automation and Bioinformatics teams to define shared requirements and contribute to cross-functional projects.
• Collect, manage, and analyze data from molecular biology and protein sequencing experiments.
• Keep a detailed electronic lab notebook on Confluence.
• Communicate and present results in a timely manner.

What you need

Required :

• Post-graduate experience in molecular biology, biochemistry, chemistry or related fields, including a:
  • BS/MS/PhD with 10+/8+/6+ years (for Staff Scientist)
  • BS/MS/PhD with 8+/6+/4+ years (for Senior Scientist)
• Track record of establishing novel assay workflows for highly sensitive molecular assays (e.g., PCR-free sequencing, single-cell assays), with clear evidence of ownership and innovation.
• Hands-on history of defining what a new component (e.g., beads, oligos, chemical handles,…