Postdoctoral Fellow - DNA repair, Epigenome

The Neuro‑Oncology Branch (NOB) at the National Cancer Institute’s Center for Cancer Research (CCR) is a specialized program dedicated to advancing the study and treatment of brain and central nervous system (CNS) tumors. We are seeking an exceptional candidate to join our Molecular and Cell Biology (MCB) Program. This position focuses on investigating DNA repair pathways in brain tumors, with an emphasis on identifying and characterizing critical epigenetic targets through genetic and biochemical approaches.

Mechanistic insights will be validated using in vitro and in vivo models, as well as patient‑derived specimens. In addition, experimental therapeutics will be developed based on preliminary findings. These discoveries are expected to provide a strong foundation for future clinical translation and therapeutic applications.

• Outstanding Training:
  Combine basic mechanistic research with disease‑relevant preclinical research.
• Advanced Models:
  Utilize both mouse models, patient‑derived xenografts (PDXs), and human specimens to develop next‑generation therapeutics.
• Collaborative Medicinal Research:
  Work in a dynamic, collaborative, and interdisciplinary research team.
• State‑of‑the‑Art Resources:
  Access state‑of‑the‑art research facilities and resources, including equipment, computational tools, and reagents.
• Exciting Research Environment:
  Benefit from well‑equipped in‑house core facilities and intense collaborations among laboratories.
• Expert Mentorship:
  Receive guidance from renowned scientists and clinicians, gaining invaluable knowledge in the field.

Degree required: Ph.D. or equivalent

Job location: Bethesda

Appointment type: Training Position (Starting stipend: $67,200)

Work schedule: Full‑time (In‑Person)

Citizenship: US citizenship or permanent residency not required

• Show interest and motivation to investigate fundamental questions in cancer biology and functional genomics.
• Leverage a background in biochemistry and molecular biology, emphasizing signal transduction, cancer cell biology, cell cycle, or DNA repair.
• Collaborate with the Principal Investigator (PI) for hypothesis development, experimental design, and execution.
• Participate in data processing, analysis, discussion, reporting, presenting findings at conferences, and manuscript drafting.
• Work effectively within an interdisciplinary team.
• Stay informed of developments in the field to maintain and enhance professional expertise.
• Perform lab maintenance, including equipment upkeep and supply ordering.
• Teach techniques to train and mentor junior research staff.
• Demonstrate excellent communication skills and fluency in both spoken and written English.

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long‑term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research.

We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies.

The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside.

Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

• CV/Resume
• 3 References
• Summary of Research Experience

Contact name: Chunzhang Yang

E‑mail address: yangc2