Scientist, Research Scientist

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

Axle is seeking a Scientist to join our vibrant team at the National Institutes of Health (NIH) supporting the National Institute of Allergy and Infectious Diseases (NIAID) located in Bethesda, MD.

• Paid Time Off and Paid Holidays
• 401K match up to 5%
• Educational Benefits for Career Growth
• Employee Referral Bonus
• Flexible Spending Accounts:
  • Healthcare (FSA)
  • Parking Reimbursement Account (PRK)
  • Dependent Care Assistant Program (DCAP)
  • Transportation Reimbursement Account (TRN)

The Scientist will lead the development of cell culture processes for clinical vaccine or therapeutic candidates s includes process technology transfer for clinical-grade material manufacture to enable clinical trials. The Scientist will establish production processes using advanced bioreactor systems and develop robust processes for toxicological-grade material generation and scalable current Good Manufacturing Practice (cGMP) production. The role also serves as the subject matter expert (SME) for technology transfer deliverables, regulatory submissions, and project planning.

A Ph.D. in Biochemistry, Chemical Engineering, or another life sciences field is required, along with 15 years of experience in mammalian and/or microbial cell culture development.

None specified

Chemical Engineering

Outlook

15 years of experience in mammalian and/or microbial cell culture development

Provide reports — Ad-Hoc

Lead development of cell culture processes for clinical vaccine or therapeutic candidates, including process technology transfer for clinical-grade material manufacture to enable clinical trials.

Serve as the SME for technology transfer deliverables, regulatory submissions, and project planning.

Establish production processes for cell culture workflows using advanced bioreactor systems and complex growth strategies.

Drive innovation and adoption of new technologies, such as scalable tangential flow filtration (TFF)-based transient transfection methods.

Support the planning and execution of research experiments in the context of the laboratory's overall research program.

Plan, design, and maintain execution of experiments that develop robust processes for toxicological-grade material generation and scalable cGMP production.

Support laboratory staff on research projects and techniques.

Maintain upstream project schedules for cell culture through coordination with project management, cell line development, and downstream processing groups.

Maintain laboratory equipment and train others in its use.

Drive an upstream/cell culture project from conception to clinical manufacturing by developing processes that require operation of bioreactors and other cell culture equipment, and provide support as required.

Assist in maintaining adequate space and facilities for ongoing and projected research studies.

Manage scientific equipment and resources (e.g., reagents, stocks of frozen cells, animal samples), including acquisition, documentation, and storage.

Participate in the laboratory's review of future proposals for resource allocation.

Evaluate, analyze, and…