Principal Scientist, Preclinical Pharmacology

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That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

The Principal Scientist / Lab Head, In Vivo Pharmacology reports to the Head of Preclinical Pharmacology and is accountable for the scientific, strategic, and operational leadership of the in vivo pharmacology function at the Billerica site. This role establishes, validates, and applies disease models — including immunological, neurological and additional therapeutic areas— to enable discovery and translational research across the N&I portfolio.

The Lab Head directly manages a team of scientists and serves as the in vivo pharmacology subject‑matter expert on cross‑functional project teams spanning biology, DMPK, biomarkers, translational medicine, and pathology.

• Lead the design, execution, interpretation, and communication of in vivo pharmacology studies in immunology, neuroscience and additional disease areas, delivering actionable scientific recommendations that directly inform N&I program progression decisions.
• Establish, validate, optimize, and troubleshoot fit-for-purpose in vivo disease models — including acute and chronic disease‑relevant models — to defined validation milestones and reproducibility criteria.
• Build and apply immunological and/or neurological disease models to evaluate efficacy, target engagement, pharmacodynamic response, and translational relevance of novel therapeutic approaches, delivering study‑ready data packages on schedule and in compliance with protocol and quality standards.
• Develop translational in vivo study strategies that connect target biology, pharmacology, PK/PD, biomarkers, and disease‑relevant outcomes, enabling evidence‑based candidate selection.
• Serve as the in vivo pharmacology subject‑matter expert on cross‑functional discovery and translational project teams, ensuring in vivo data are correctly interpreted and integrated into program strategy.
• Provide clear scientific recommendations on model selection, study design, endpoints, dosing regimens, and program progression to accelerate candidate advancement.
• Contribute to target validation, candidate selection, mechanism‑of‑action studies, and translational pharmacology packages supporting IND-enabling decisions.

• Hands on execution of in vivo pharmacology studies in disease models — including dosing via IV, SC, IP, PO, ICV, and IT routes, blood and CSF sampling, tissue collection, and necropsy — delivering study‑ready samples on schedule and in compliance with protocol and quality standards.
• Perform and support surgical…