Principal Software Development Eng

Principal Software Development Engineer – Billerica, MA (Hybrid)

Quanterix is a global leader in ultra-sensitive biomarker detection, enabling breakthroughs in disease research, diagnostics, and drug development. Its proprietary Simoa technology delivers industry-leading sensitivity, allowing researchers to detect and quantify biomarkers in blood and other fluids at concentrations far below traditional limits. With more than 3,400 peer‑reviewed publications, Quanterix has been a trusted partner to the scientific community for nearly two decades.

In 2025, Quanterix acquired Akoya Biosciences, The Spatial Biology Company, adding multiplexed tissue imaging with single‑cell resolution to its portfolio. Together, the combined company offers a uniquely integrated platform that connects biology across blood and tissue, advancing precision medicine from discovery to diagnostics.

The Principal Software Development Engineer is a senior member providing significant contributions to the architecture, design, development and test suite of Spatial Biology software products. Spatial Biology software products include GUI, instrument control layers (including firmware), image viewers, and image analysis software. This position may be the primary development lead on some products and will serve as the primary point of contact for more junior members.

The Principal Software Development Engineer is also the liaison between the Software Team and other technical groups within the product development process. As you become an expert in Spatial Biology products, there will be opportunities to contribute to ultra‑sensitive protein detection products as well.

• Demonstrate significant knowledge in overall design, development, and delivery of Akoya's software solutions, particularly those used to interface with/control our instrument portfolio.
• Own the design and development of significant portions of products, or entire small products themselves.
• Own the interaction between the hardware and software; primary diagnostician for potential hardware/software issues.
• Capable of leading junior team members in construction and maintenance of the codebase.
• Provides technical support and solutions to junior team members.
• Works with minimal supervision; uses a wide degree of creativity and latitude to solve problems.
• Handles software releases.

• Bachelor's degree in a related area (Master's in related area preferred).
• 10+ years of experience in software development.

• Previous experience as a principal or Sr Software Developer, with increasing responsibilities over time.
• Participate in cross‑functional programs with the ultimate goal of developing products.

• Billerica, MA (Hybrid – onsite as needed for work with the hardware; days can vary).
• Expert knowledge of programming in C#, C++.
• Extensive experience working with .NET Framework, WPF and Winform solutions.
• Experience with front and backend architecture (including authoring mockups as part of UI design).
• Experience with Microsoft Development tools (Visual Studio, MSBuild, Power Shell).
• Experience with various source code management systems (Git Hub, Mercurial, Subversion).
• Experience with Test Drive Development/Unit test technologies (NUnit, XUnit, MSTest).
• Experience with Automation Test frameworks (FlaUI, Ranorex, Cypress).
• Experience with one or more aspects of instrument control, such as image acquisition (frame grabbers), XYZ stage control, stepper motors/encoder control, and/or fluidics control (syringe pumps, etc.).
• Familiarity with Agile development methodology.
• Excellent verbal and written communication skills as well as team‑building and interpersonal skills.

Our Technology
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From discovery to diagnostics, Quanterix's ultrasensitive biomarker detection is fueling breakthroughs only made possible through its unparalleled sensitivity and flexibility. Simoa technology has delivered the gold standard for earlier biomarker detection in blood, serum or plasma, with the ability to quantify proteins that are far lower than the Level of Quantification (LoQ).…