Research Fellow - Department of Cancer and Genomic Sciences Grade 7

Position Details

Department of Cancer and Genomic Sciences, College of Medicine and Health

Location:

University of Birmingham, Edgbaston, Birmingham UK

Full time starting salary is normally in the range £36,636 to £46,049 with potential progression once in post to £48,822

Grade: 7

Full Time, Fixed Term contract up to January 2029

Closing date: 2nd March 2026

This role is also open as an internal secondment opportunity which would need to be agreed by your current line manager.

To create and contribute to the creation of knowledge by undertaking a specified range of activities within an established research programme and/or specific research project.

This Wellcome Trust-funded post is established to study the mechanisms of transcriptional control of mRNA fate in development. The post holder will be part of a multi-disciplinary research team within the Department of Cancer and Genomic Sciences. Their main role will be to apply and develop new methods of precise genome manipulation and subsequent in vivo phenotyping (e.g. high resolution 4D imaging) and molecular analysis (transcriptomics, metabolomics) of zebrafish embryo models.

They will develop transgenic and mutant models for transcriptional regulation of post-transcriptional mRNA fate focussing on transcription initiation dependent mRNA diversification. They will answer questions about how transcription control on promoter level contributes to metabolic adaptation and response to metabolic stress in development. They will perform and develop assays for in vivo detection of metabolic shifts by transgenic and other reporter activity and will work together with genomics experts and those seeking mechanism of translation regulation of mRNAs in the same programme.

The post is available for 3 years.

• Work within specified research grants and projects and contribute to writing bids
• Operate within area of functional genomics and developmental genetics
• Analyse and interpret research findings and results by embryo phenotyping by genomics and imaging tools, publish high quality new results in peer reviewed journals
• Contribute to generating funding for further research in the area
• Contribute to licensing or spin out deals with demonstrated commercial success (such as revenues, asset or company sales, IP generated) and/or public understanding of the discipline or similar

The responsibilities may include some but not all of the responsibilities outlined below.

• Develop research objectives and proposals for own or joint research, with assistance of a mentor if required
• Contribute to writing bids for research funding
• Analyse and interpret genomics, embryo phenotyping and developmental genetic data
• Apply knowledge in a way which develops new intellectual understanding of transription control
• Disseminate research findings for peer reviewed publication, research seminars conferences and consortium meetings
• Supervise students on wet lab research and provide guidance to PhD students where appropriate to the developmental genetics, functional genomics
• Contribute to developing new models, techniques and methods in genome editing and manipulation, in vivo phenotyping
• Design experiments, new research studies and develop new projects within the research topic
• Undertake management/administration arising from research within the consortium and the wider research team
• Contribute to Departmental/School research-related activities and research-related administration
• Contribute to enterprise, business development and/or public engagement activities of manifest benefit to the College and the University, often under supervision of a project leader
• Collect research data; this may be through a variety of research methods, such as scientific experimentation, literature reviews
• Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
• Provide guidance, as required, to support staff and any students who may be assisting with the research
• Deal with problems that may affect the achievement of research objectives and deadlines
• Promotes equality and values diversity acting as a role model and fostering an…