Senior Accountant

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Senior Accountant

Full-time, hybrid role based in Boston, MA

About Hot Spot Therapeutics, Inc.

At Hot Spot Therapeutics, nature is inspiring us to create a wave of new medicines. Through a proprietary technology platform, we are uncovering privileged allosteric sites used by nature to control proteins – calledregulatory hotspots- that can be exploited through small molecule drug discovery. Regulatory hotspots are allowing sought-after targets to be drugged for the first time while delivering molecules with exquisite selectivity and attractive drug-like properties.

At Hot Spot, we’re not just looking for the brightest minds or for the most brilliant individual contributors. We want passionate team members who are comfortable adjusting their lens, aren’t afraid to think big, test bold ideas, and celebrate collective wins. We have established core values that resemble who we are and define our company culture. We are building a company where values drive everything we do inside and outside the organization

#Courageous Adventurers #Leave your Mark #Keep it Human #Make it Real

SUMMARY:

The Senior Accountant will play a key role in driving our financial operations, ensuring accurate and timely reporting, and enforcing strong internal controls. While the primary focus of this role is on core accounting functions, the Senior Accountant will also independently manage certain aspects of contract administration as part of broader operational responsibilities. This includes overseeing contract documentation and workflow management with minimal supervision, requiring exceptional attention to detail and organizational skills.

RESPONSIBILITIES:

·Take ownership of the month-end close process, ensuring all financial transactions are accurately recorded and reported within strict deadlines. Independently prepare complex journal entries, perform in-depth account reconciliations, and proactively investigate and resolve discrepancies. Uphold rigorous internal controls and continuously implement process improvements to optimize the efficiency and accuracy of financial reporting.

· Manage cash reconciliations and lead the preparation of monthly financial statements and reporting packages.

· Oversee accounts payable operations and ensure timely, accurate vendor payments in compliance with internal controls.

· Administer expense reporting systems, maintain vendor records, and manage annual 1099 filings.

· Independently process semi-monthly payroll and ensure full compliance with all applicable state tax regulations.

· Lead the preparation of materials for financial audits and tax compliance reporting.

· Enforce and strengthen internal controls, identifying and executing opportunities for process improvement and increased efficiency.

· Manage procurement activities and ensure strict compliance with accounting policies during the purchasing process.

Contracts Administration Support:

· Take responsibility for reviewing, tracking, and organizing contract documentation.

· Independently coordinate with internal teams to manage contract workflows and approvals.

· Monitor upcoming renewals and ensure proper archiving of executed contracts.

· Lead ad-hoc projects and reporting initiatives as needed, delivering high-quality results with minimal supervision.

QUALIFICATIONS:

·Bachelor’s degree in Accounting, Finance, or a related field.

· 3+ years of relevant accounting experience; biotech or pharmaceutical industry experience strongly preferred.

· Highly organized and detail-oriented, with expert-level reconciliation and analytical skills.

· Strong written and verbal communication skills; confident interacting with internal teams, external partners, and senior management.

· Excellent time management skills with the ability to independently prioritize and meet multiple critical deadlines.

· A proactive, self-starter mindset with the confidence to take ownership of tasks and drive them to completion.

· Familiarity with Net Suite, Coupa, and…