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Senior Manager Managed Markets and Gross to Net Analytics

Job in Boston, Suffolk County, Massachusetts, 02298, USA
Listing for: Vertex Pharmaceuticals Incorporated
Full Time position
Listed on 2026-01-12
Job specializations:
  • Business
    Financial Manager
  • Finance & Banking
    Financial Manager
Salary/Wage Range or Industry Benchmark: 150000 - 200000 USD Yearly USD 150000.00 200000.00 YEAR
Job Description & How to Apply Below

Job Description

Vertex Pharmaceuticals Inc. is seeking a Senior Manager reporting to the Director of Managed Markets Operations, Pricing and Analytics, US Managed Markets. This role offers the right candidate an exceptional opportunity to join our team during a time of dynamic growth. This position will help develop and strengthen the understanding of the rapidly evolving US pricing & payer dynamics, as well as approaches and tools towards developing cohesive and comprehensive forecasts.

In addition, the position will help expand your horizons through opportunities to interact with US and Global teams. The Senior Manager will play a meaningful role in supporting the day to day operations of the Managed Markets Analytics group. You will not only have a vital role in our growing team, but also join a company that is working towards tomorrow's breakthrough medicines.

The Senior Manager of Gross-to-Net and Managed Markets Analytics role provides leadership for key strategic business processes by managing the gross-to-net (GTN) inputs, projections, and assessments for our US operations. In addition, the Senior Manager will conduct sophisticated analyses, develop financial models, and present their findings effectively and succinctly to executive leadership. This role requires the extraction and synthesis of relevant data and timely provision of insights on the underlying factors driving forecasts and causes of variances to plan.

The ideal candidate will demonstrate a strong understanding of the US Managed Markets landscape, analytical thinking, technical sophistication, and operational efficiency.

The individual will also play a key role in the monthly US Revenue and Long-Range Planning forecast processes via strategic analyses, recommendations and oversight of highly visible reports and relevant models supporting commercial Cystic Fibrosis medicines and, as requested, certain pipeline Vertex assets.

This role will collaborate closely with Accounting, Commercial FP&A, Government/Public Affairs, Legal, Business Information & Commercial Operations (BICO) teams and senior Commercial leadership on a regular basis. This individual will also serve as a subject matter expert to ensure internal stakeholder understanding and anticipation of the impact of key policy changes and payer mix trends impacting the business and access to Vertex medicines.

Key Responsibilities
  • Drive GTN Close and Forecast processes and analyze, explain, and meaningfully summarize gross to net variances by channel and segment
  • Prepare monthly GTN forecast by leveraging excel models and conducting secondary data analytics
  • Lead monthly GTN review meetings with US Finance leadership with a focus on disseminating key variance drivers. Integrate and analyze relevant pricing and utilization data to inform trends and forecast adjustment recommendations to senior leadership in the form of standard reports or business cases.
  • In support of long-range planning and annual corporate net revenue and budget processes, provide strategic oversight and ensure accuracy of modeling assumptions, trend analyses and forecast recommendations related to payer mix and gross-to-net
  • Lead coordination with Accounting, BICO, Finance, Global Market Access, Government/Public Affairs and Managed Markets leadership to gain alignment on assumptions and inputs
  • Provide timely analyses of potential statutory and regulatory changes the Vertex's business (e.g. MFN, value-based arrangements, multiple Best Prices etc.)
  • Development of a bi-annual industry price increase report that highlights key pricing trend tracking across different segments and product classes in the biopharma industry
  • Serve as a subject matter expert on trends related to key drivers of gross-to-net through proactive analysis of various data sources, industry publications and engagement of internal/external stakeholders.
  • Responsible for analyzing and creating presentations for senior and executive management that summarize trends, forecasts and potential financial impact of new and pending state and federal policies, pricing scenarios and payer mix
  • Generate new ideas for business analytics that add value by deepening the company's understanding of key payer/channel/pricing trends and the impact on Vertex
Minimum Qualifications
  • A Bachelor's degree (Masters' Degree in Finance, Business, Public Policy or Data Science preferred)
  • 6+ years of experience in the pharmaceutical or biotech industry with focus on business analytics and forecasting is required.
  • Ability to mine data to identify trends
  • Exceptional in conducting complex data analytics, attention to detail and technical data skills
  • Ability to synthesize complex business questions and perform quantitative analysis to identify implications
  • Expert modeling skills with advanced proficiency in Microsoft Excel and PowerPoint required
  • Ability to communicate confidently and clearly to senior leaders on multifaceted market access and pricing drivers, including excellent written and verbal…
Position Requirements
10+ Years work experience
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