Operational Excellence & Business Analytics Associate Director

Vertex is a global biotechnology company focused on investing in scientific innovation to create transformative medicines for people with serious diseases. Across our organization, we work with urgency, rigor, and collaboration to deliver therapies that improve patient outcomes and create long‑term value.

The Operational Excellence & Business Analytics team serves as the process improvement and performance enablement backbone of CMTO, providing the integrated performance visibility, standardized metrics, and improvement discipline required to run, grow, and optimize Vertex's external commercial manufacturing network. The Associate Director, Operational Excellence & Business Analytics is an end‑to‑end role that combines capabilities into a single accountability: the ability to (1) translate enterprise‑and asset‑level performance data into a coherent, decision‑ready view of the network and its individual components, and (2) prioritize and drive the improvement initiatives those insights demand, and (3) present to cross‑functional leadership.

The role partners closely with Network Performance, Manufacturing Operations, MS&T, Business Operations Leads, and Finance to embed data‑driven decision‑making and continuous improvement into CMTO's governance and operating rhythms. This position will serve as a strategic change agent and analytics translator, advancing CMTO's operational excellence culture by demonstrating quantifiable benefits from improvement initiatives, mentoring teams on lean methods and data fluency, and ensuring decisions across the network are traceable, measurable, and reviewable.

Contribute to setting CMTO's operational excellence strategy, priorities, and success measures, aligned to enterprise and functional priorities. Identify, prioritize, and drive execution of a portfolio of commercial manufacturing improvement and transformation initiatives — partnering with sites and functions while avoiding ownership of routine operations. Lead initiatives targeting lead‑time reduction, launch optimization, yield, and manufacturing success‑rate improvements and COGM reduction through structured problem definition, root‑cause analysis, options analysis, and ROI calculation.

Lead Lean, Six Sigma, Kaizen, Value Stream Mapping, and structured problem‑solving initiatives across technical and business processes.

Build and maintain an integrated performance view across network performance, asset execution, readiness, cost, and delivery — ensuring defined KPIs are observable in practice through consistent data availability, structure, and integrity. Establish and maintain standard dashboards, metrics, and systems of record that enable consistent CMTO LT and enterprise‑level visibility and comparability. Partner with Network Performance to translate performance standards into reportable, automated views;

partner with Digital Technology & Engineering on digital transformation plans that improve access to accurate, timely data.

Support scenario analysis and trade‑off evaluations for network, asset, and portfolio decisions by making assumptions, options, and implications transparent — without owning execution. Enable data‑driven governance by ensuring decisions, assumptions, and outcomes are traceable, measurable, and reviewable in CMTO and enterprise governance forums. Prepare executive‑ready materials, performance narratives, and recommendations for governance reviews and leadership decisions.

Embed learning, improvement discipline, and change…